Luis Pereira de Almeida

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Associate Professor

University of Coimbra

Portugal

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About

Luis Pereira de Almeida is an Associate Professor at the University of Coimbra, Portugal. His research focuses on therapeutic potentials related to circadian rhythm sleep disorders, neurodegenerative diseases, and spinocerebellar ataxia type 3. He has published extensively on topics including the effects of melatonin, autophagy, and innovative approaches in vaccine development against COVID-19. His work also explores the molecular mechanisms underlying neuronal health and disease through various experimental methodologies.

Recent Grants

Grant: Close

Genome editing to rescue Machado-Joseph disease by alternative splicing

Open Date: 2022-01-01

Close Date: 2023-06-30

Grant: Close

Assessing aging of human neurons by direct induced neuronal iN conversion

Open Date: 2021-03-01

Close Date: 2024-02-29

Grant: Close

ARDAT Accelerating research & development for advanced therapies- Innovative Medicines Initiative. EU Grant agreement number 945473. WP3 Co-lead.

Open Date: 2020-11-01

Close Date: 2025-01-01

Grant: Close

Center for Innovative Biomedicine and Biotechnology

Open Date: 2020-01-01

Close Date: 2023-12-31

Grant: Close

Center for Innovative Biomedicine and Biotechnology

Open Date: 2020-01-01

Close Date: 2023-12-31

Articles (30)

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Polyglutamine disorders are a complex group of incurable neurodegenerative disorders caused by an abnormal expansion in the trinucleotide cytosine-adenine-guanine tract of the affected gene. To better understand these disorders, our dependence on animal models persists, primarily relying on transgenic models. In an effort to complement and deepen our knowledge, researchers have also developed animal models of polyglutamine disorders employing viral vectors. Viral vectors have been extensively used to deliver genes to the brain, not only for therapeutic purposes but also for the development of animal models, given their remarkable flexibility. In a time- and cost-effective manner, it is possible to use different transgenes, at varying doses, in diverse targeted tissues, at different ages, and in different species, to recreate polyglutamine pathology. This paper aims to showcase the utility of viral vectors in disease modelling, share essential considerations for developing animal models with viral vectors, and provide a comprehensive review of existing viral-based animal models for polyglutamine disorders.

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2024

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2023

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2022

Collaborators (102)

VIKRAMSINGH GUJAR

Assistant Professor

University of Oklahoma Health Sciences Center

UNITED STATES

Luis Pereira de Almeida

Research Interests

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About

Recent Grants

Articles (30)

The Therapeutic Potential of Melatonin and Its Novel Synthetic Analogs in Circadian Rhythm Sleep Disorders, Inflammation‐Associated Pathologies, and Neurodegenerative Diseases

Autophagy- and oxidative stress-related protein deregulation mediated by extracellular vesicles of human MJD/SCA3 iPSC-derived neuroepithelial stem cells and differentiated neural cultures

Fourier Transform Infrared Spectroscopy Analysis as a Tool to Address Aβ Impact on Extracellular Vesicles

Exploring TLR agonists as adjuvants for COVID-19 oral vaccines

Progression of biological markers in spinocerebellar ataxia type 3: longitudinal analysis of prospective data from the ESMI cohort

Regional distribution of polymorphisms associated to the disease-causing gene of spinocerebellar ataxia type 3

Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice

Spinocerebellar ataxia type 3: from pathogenesis to promising therapeutics

Viral-based animal models in polyglutamine disorders

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.

MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress

Modeling Lysosomal Storage Disorders in an Innovative Way: Establishment and Characterization of Stem Cell Lines from Human Exfoliated Deciduous Teeth of Mucopolysaccharidosis Type II Patients

Factors Influencing Health-Related Quality of Life of Patients with Spinocerebellar Ataxia.

Molecular therapy for polyQ disorders: from bench to clinical trials

Graft-derived neurons and bystander effects are maintained for six months after human iPSC-derived NESC transplantation in mice’s cerebella

Phosphoproteome Microarray Analysis of Extracellular Particles as a Tool to Explore Novel Biomarker Candidates for Alzheimer’s Disease

Brain-targeted drug delivery - nanovesicles directed to specific brain cells by brain-targeting ligands

Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads

Isolation of Adeno-associated Viral Vectors Through a Single-step and Semi-automated Heparin Affinity Chromatography Protocol

Mannose and Lactobionic Acid in Nasal Vaccination: Enhancing Antigen Delivery via C-Type Lectin Receptors

The frequency of non-motor symptoms in SCA3 and their association with disease severity and lifestyle factors

A standardized protocol for blood and cerebrospinal fluid collection and processing for biomarker research in ataxia

Isolation of Extracellular Vesicles from Human Follicular Fluid: Size-Exclusion Chromatography versus Ultracentrifugation

Ataxin-2 in the hypothalamus at the crossroads between metabolism and clock genes

In Vitro Evaluation of Biphasic Calcium Phosphate Scaffolds Derived from Cuttlefish Bone Coated with Poly(ester urea) for Bone Tissue Regeneration

Consensus Recommendations for Clinical Outcome Assessments and Registry Development in Ataxias: Ataxia Global Initiative (AGI) Working Group Expert Guidance

Extracellular communication between brain cells through functional transfer of Cre mRNA mediated by extracellular vesicles

Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3

SCAview: an Intuitive Visual Approach to the Integrative Analysis of Clinical Data in Spinocerebellar Ataxias

A new protocol for whole-brain biodistribution analysis of AAVs by tissue clearing, light-sheet microscopy and semi-automated spatial quantification

Collaborators (102)

VIKRAMSINGH GUJAR

Ramaroson Andriantsitohaina

Oscar Wiklander

Pia Siljander

Ludger Schöls

Elena Martens-Uzunova

Michele Zanoni

Eduardo Reátegui

Sveva Bollini

Célia M. F. Gomes

Kirsty Danielson

Miguel Flores-Bellver

Anna Krasnodembskaya

Lucia Paolini

Jameel Inal

Julie Saugstad

Esmeralda Martins

Irina Nazarenko

Marta Garcia-Contreras

Fatemeh Momen-Heravi

Albano Caceres-Verschae

Jennifer Jones

Maiken Mellergaard

Kimberley Louise Alexander

Christian Neri

Ann M Wehman

Lesley Cheng

Kathrin Reetz

Rachel Crossland

Daniel Kim

Suman Dutta

Deborah Goberdhan

FRANCESC E. BORRAS

Jason Webber

Mona Batish

Aurélie Ledreux

Tsuneya Ikezu

Manuela Lima

Cécile MALNOU

José Rino

Mikael Klingeborn

John Miklavcic