Birger Brodin

Professor, CNS Drug Delivery

University of Copenhagen

Denmark

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About

Birger Brodin is a Professor of CNS Drug Delivery at the University of Copenhagen, Denmark. His research focuses on drug delivery systems and blood-brain barrier dynamics, including the characterization of blood-brain barrier transporters and the impact of various peptides on barrier integrity. Recent articles highlight his work on improved drug uptake mechanisms and pharmacokinetics assessment in animal models.

Articles (11)

Year:

2024

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2023

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2023

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2023

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2022

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2022

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2022

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2022

Year:

2022

Year:

2022

Year:

2021

Collaborators (12)

Serge Luquet

Université Paris Cité

FRANCE

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Lasse Saaby

Københavns Universitet

DENMARK

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Chiara Saponaro

Associate Professor

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Birger Brodin

Research Interests

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About

Articles (11)

Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus

Assessing extent of brain penetration in vivo (Kp,uu,brain) in Göttingen minipig using a diverse set of reference drugs

Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells

SorLA in astrocytes regulates blood-brain barrier integrity

Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers

Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions

Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established <i>in vitro</i> to <i>in vivo</i> extrapolation methodologies

The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood–Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood–Brain Barrier In Vitro and In Vivo

Sortilin regulates blood–brain barrier integrity

Highly cationic cell-penetrating peptides affect the barrier integrity and facilitates mannitol permeation in a human stem cell-based blood-brain barrier model

Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice

Collaborators (12)

Serge Luquet

Lasse Saaby

Chiara Saponaro

Peter Loof Møller

Hans Christian Cederberg Helms

Andrea E. Toth

Annette Burkhart Larsen

Anders Bach

Maj Schneider Thomsen

Mie Kristensen

Morten Schallburg Nielsen

András Harazin

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