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Lasse Saaby

Københavns Universitet

Denmark

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Research Interests

Pharmacology

90%

Tissue Engineering

30%

Antimicrobial Research

40%

In Vitro Studies

30%

Gut Microbiota

30%

Bioactive Compound

30%

Blood-brain Barrier

30%

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Articles16

Inhibition of ABCG2 by SCO-101 Enhances Chemotherapy Efficacy in Cancer

Article Link

Year:

2025

Permeation Enhancer‐based Ionogel Shows Remarkable Potential for Oral Insulin Delivery

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Year:

2025

Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation

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Year:

2024

Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution

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Year:

2024

Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus

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Year:

2024

The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells

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Year:

2024

Barrier properties of ex vivo porcine intestinal mucus are highly independent of isolation and storage conditions

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Year:

2022

Physical and barrier changes in gastrointestinal mucus induced by the permeation enhancer sodium 8-[(2-hydroxybenzoyl)amino]octanoate (SNAC)

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Year:

2022

Insight Into the Anti-staphylococcal Activity of JBC 1847 at Sub-Inhibitory Concentration

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Year:

2022

Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice

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Year:

2021

A new phenothiazine derivate is active against Clostridioides difficile and shows low cytotoxicity

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Year:

2021

Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5)

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Year:

2021

Efficacy of a novel antimicrobial hydrogel for eradication of Staphylococcus epidermidis, Staphylococcus aureus and Cutibacterium acnes from preformed biofilm and treatment performance in an in vivo MRSA wound model

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Year:

2021

Gluten Degradation, Pharmacokinetics, Safety, and Tolerability of TAK-062, an Engineered Enzyme to Treat Celiac Disease

Article Link

Year:

2021

A novel derivative of thioridazine shows low toxicity and efficient activity against gram‐positive pathogens

Article Link

Year:

2020

Ipec-j2 rmdr1a and a new cell line with functional expression of rat p-glycoprotein encoded by rat mdr1a for drug screening purposes

Article Link

Year:

2020

Collaborators12

Andrew Williams

Associate Professor

University of Copenhagen

DENMARK

Hanne Mørck Nielsen

Københavns Universitet

DENMARK

Stine Rønholt

Københavns Universitet

DENMARK

Lasse Krog

Københavns Universitet

DENMARK

Birger Brodin

Professor, CNS Drug Delivery

University of Copenhagen

DENMARK

Michael Gajhede

Københavns Universitet

DENMARK

Janne Kudsk Klitgaard

University of Southern Denmark

DENMARK

Vanessa Hall

Københavns Universitet

DENMARK

Mie Kristensen

Københavns Universitet

DENMARK

Johan Boetker

Københavns Universitet

DENMARK

Cristiana Cunha

Københavns Universitet

DENMARK

Jørn Bolstad Christensen

Københavns Universitet

DENMARK

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