Brian Callahan

Associate Professor

Binghamton University

United States

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Brian Callahan is an Associate Professor at Binghamton University in the United States. His research focuses on Hedgehog signaling, cancer drug discovery, and enzymatic processes, as evidenced by his recent publications. His work includes the study of protein autoprocessing and the development of assays for identifying inhibitors and activators of related proteins.

Articles (7)

Year:

2025

Year:

2023

Year:

2022

Year:

2022

Year:

2022

Year:

2020

Year:

2020

Collaborators (3)

Chunyu Wang

Professor

Rensselaer Polytechnic Institute

UNITED STATES

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Nathan Smith

Research/Teaching Assistant

Rensselaer Polytechnic Institute

UNITED STATES

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Eriks Rozners

Professor

Binghamton University

UNITED STATES

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Brian Callahan

Research Interests

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Articles (7)

Conserved C143 forms a branched intermediate in Hedgehog autoprocessing: A cancer drug discovery target against Hedgehog signaling

There’s more to enzyme antagonism than inhibition

A cell-based bioluminescence reporter assay of human Sonic Hedgehog protein autoprocessing to identify inhibitors and activators

Nanomolar, Noncovalent Antagonism of Hedgehog Cholesterolysis: Exception to the “Irreversibility Rule” for Protein Autoprocessing Inhibition

Enzymatic Beacons for Specific Sensing of Dilute Nucleic Acid**

Specificity Distorted: Chemical Induction of Biological Paracatalysis

Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis

Collaborators (3)

Chunyu Wang

Nathan Smith

Eriks Rozners

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