Brian Pierce

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University of Maryland

United States

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Recent Grants

Grant: Open

Rational design and efficacy testing of vaccines against HCV

Open Date: 2022-05-05

Close Date: 2027-04-30

Grant: Open

High resolution modeling and design of immune recognition

Open Date: 2022-01-01

Close Date: 2026-12-31

Grant: Close

Design of immunologically intact soluble HCV E1E2 complexes using transmembrane-mimic scaffolds

Open Date: 2020-06-01

Close Date: 2022-05-31

Grant: Close

High Resolution Modeling and Design of T-Cell Receptors

Open Date: 2018-09-01

Close Date: 2022-05-31

Grant: Close

Structure-Based Vaccine Design for Hepatits C Virus

Open Date: 2017-06-01

Close Date: 2022-05-31

Articles (20)

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2021

Collaborators (21)

Alexandre M.J.J. Bonvin

Utrecht University

NETHERLANDS

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Balraj Doray

Associate Professor of Medicine

Washington University in Saint Louis School of Medicine

UNITED STATES

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Ragul Gowthaman

University of Maryland

UNITED STATES

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Jiang-Yuan Li

University of Gothenburg

SWEDEN

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Amitabh Varshney

University of Maryland

UNITED STATES

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Romina Oliva

Associate Professor

Università degli Studi di Napoli Parthenope

ITALY

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Masakazu Sekijima

JAPAN

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Andrey Alekseenko

KTH Royal Institute of Technology

SWEDEN

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Steven Foung

Professor

Stanford University

UNITED STATES

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Rafal Slusarz

University of Gdańsk

POLAND

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Debajit Dey

UNITED STATES

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Alexander Tarr

Assistant Professor

University of Nottingham

UNITED KINGDOM

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Richard Urbanowicz

Lecturer in Infection Immunology

University of Liverpool

UNITED KINGDOM

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Adam K. Sieradzan

University of Gdańsk

POLAND

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Enya Qing

Research Assistant Professor

Loyola University Chicago

UNITED STATES

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Martyna Maszota-Zieleniak

University of Gdańsk

POLAND

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Jonathan Du

Lecturer

University of Sydney

AUSTRALIA

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Tsukasa Nakamura

Postdoctoral Research Fellow

JAPAN

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Nicholas Schnicker

Iowa State University

UNITED STATES

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Guillaume Brysbaert

CNRS

FRANCE

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Paul Bates

Head of Biomolecular Modelling Laboratory

The Francis Crick Institute

UNITED KINGDOM

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Brian Pierce

Research Interests

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Recent Grants

Articles (20)

TCR3d 2.0: expanding the T cell receptor structure database with new structures, tools and interactions

Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers

Proscan: a structure-based proline design web server

Evaluation of AlphaFold antibody–antigen modeling with implications for improving predictive accuracy

Exploring the potential of structure-based deep learning approaches for T cell receptor design

Structural insights into protection against a SARS-CoV-2 spike variant by T cell receptor diversity.

A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs.

Impact of <scp>AlphaFold</scp> on structure prediction of protein complexes: The <scp>CASP15‐CAPRI</scp> experiment

SARS-CoV-2 infection establishes a stable and age-independent CD8<sup>+</sup> T cell response against a dominant nucleocapsid epitope using restricted T cell receptors.

Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies

TCRmodel2: high-resolution modeling of T cell receptor recognition using deep learning

Induction of broadly neutralizing antibodies using a secreted form of the hepatitis C virus E1E2 heterodimer as a vaccine candidate

Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors

An Antigenically Diverse, Representative Panel of Envelope Glycoproteins for Hepatitis C Virus Vaccine Development

An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking

Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants.

Benchmarking AlphaFold for protein complex modeling reveals accuracy determinants

T cell receptors employ diverse strategies to target a p53 cancer neoantigen.

Prediction of protein assemblies, the next frontier: The CASP14‐CAPRI experiment

Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variants.

Collaborators (21)

Alexandre M.J.J. Bonvin

Balraj Doray

Ragul Gowthaman

Jiang-Yuan Li

Amitabh Varshney

Romina Oliva

Masakazu Sekijima

Andrey Alekseenko

Steven Foung

Rafal Slusarz

Debajit Dey

Alexander Tarr

Richard Urbanowicz

Adam K. Sieradzan

Enya Qing

Martyna Maszota-Zieleniak

Jonathan Du

Tsukasa Nakamura

Nicholas Schnicker

Guillaume Brysbaert

Paul Bates

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