Carl Herrmann

This PhD project, titled "Inferring Circadian Dynamics in mRNA Dynamics During Aging (Computing-Rhythms)," is offered at Heidelberg University within the HBIGS Heidelberg Biosciences International Graduate School. The research aims to unravel how aging affects circadian changes in mRNA processing and expression, focusing on endothelial cells in mouse tissues. These cells are crucial for vascular function, and their age-related decline is thought to precede broader organismal aging. The project will leverage both experimental and computational approaches, integrating public and in-house cross-species datasets to provide deeper insights into temporal gene regulation and transcriptional dynamics. The successful candidate will join an interdisciplinary environment, working closely with the experimental AngioRhythms research group led by Dr. Mahak Singhal at the Medical Faculty Mannheim and the computational Biomedical Genomics laboratory of Prof. Dr. Carl Herrmann at the Medical Faculty Heidelberg. The position offers scientific independence, flexibility, and the opportunity to collaborate with both dry-lab and wet-lab experts, fostering personal and professional development. Applicants should possess a Master's degree or equivalent in biological sciences or a related field, with strong computational skills, particularly in R and Python. Fluency in English and the ability to work effectively in a team are essential. The position is fully funded for three years through the EU Vascular-Rhythm grant, providing financial security and support for the duration of the project. Applications must be submitted exclusively via the HBIGS application system. The deadline for applications is May 10, 2026, and the position is available from July 1, 2026. For more information and to apply, visit the HBIGS application portal. For further details, candidates may consult the research group websites or contact the graduate school directly.