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Carolien van de Sandt

Has grant

Team Leader/Senior Research Fellow

Murdoch Childrens Research Institute

Australia

Research Interests

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Professors in Australia Professors in Immunology Immunology professors in Australia

Recent Grants

Grant: Open

Restoring immunity across the human lifespan and in high-risk populations

Open Date: 2025-01-01

Close Date: 2029-12-01

Grant: Close

Supporting healthier lives of elderly people

Open Date: 2024-01-01

Close Date: 2025-01-01

Grant: Close

Defining key mediators of life-threatening disease across emerging and re-emerging viral infections, age groups and vulnerable populations.

Open Date: 2024-01-01

Close Date: 2026-01-01

Grant: Open

COVID-19 vaccine and chimeric antigen receptor T cell therapies for breast cancers

Open Date: 2023-01-01

Close Date: 2026-12-01

Grant: Close

Decoding the evolution of killer T cell immunity across human lifetime

Open Date: 2022-01-01

Close Date: 2024-01-01

Articles (19)

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Collaborators (38)

Louise Rowntree

University of Melbourne

AUSTRALIA

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Dene Littler

MONASH UNIVERSITY

AUSTRALIA

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Kristen Radford

The University of Queensland

AUSTRALIA

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Nicole La Gruta

Department Head

MONASH UNIVERSITY

AUSTRALIA

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Amy W Chung

University of Melbourne

AUSTRALIA

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David Lynn

Professor

Flinders University School of Medicine

AUSTRALIA

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Tobias Kollmann

Professor

Dalhousie University

CANADA

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Anastasia Minervina

Staff Scientist

Fred Hutch Cancer Center

UNITED STATES

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THI HOANG OANH NGUYEN

University of Melbourne

AUSTRALIA

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Jennifer Habel

University of Melbourne

AUSTRALIA

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Sophie A Valkenburg

Associate Professor

University of Melbourne

AUSTRALIA

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Julio Cesar Carrera Montoya

University of Melbourne

AUSTRALIA

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DirkJan Hijnen

Erasmus University Rotterdam

NETHERLANDS

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Sander W. Tas

Professor of Rheumatology

Amsterdam UMC, University of Amsterdam

NETHERLANDS

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James A Triccas

University of Sydney

AUSTRALIA

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Hayley McQuilten

Peter Doherty Institute

AUSTRALIA

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Michael Gibbons

Honorary Associate Clinical Professor

University of Exeter

UNITED KINGDOM

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Caitlin Uren

Senior Lecturer

Stellenbosch University

SOUTH AFRICA

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Klaas P.J.M. van Gisbergen

NETHERLANDS

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Susan Phillipa Walker

Professor

University of Melbourne

AUSTRALIA

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Natalie Stevens

South Australian Health and Medical Research Institute

AUSTRALIA

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Jillian Lau

Peter Doherty Institute

AUSTRALIA

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Wenna Lee

University in Western Australia

AUSTRALIA

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James McMahon

MONASH UNIVERSITY

AUSTRALIA

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Patricia Illing

Monash University Malaysia.

AUSTRALIA

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Benedikt Obermayer

Berlin Institute of Health at Charité - Universitätsmedizin Berlin

GERMANY

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Claudio Counoupas

Conjoint Lecturer

University of Sydney

AUSTRALIA

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Katie Nicol

Senior Research Fellow

University of Melbourne

AUSTRALIA

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Isabelle Jia Hui Foo

University of Melbourne

AUSTRALIA

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Branka Grubor-Bauk

Associate Professor

University of Adelaide

AUSTRALIA

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Rob ter Heine

NETHERLANDS

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Miriam Anne Lynn

Flinders University

AUSTRALIA

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Katherine Kedzierska

Laboratory Head, Deputy Head of Department

University of Melbourne

AUSTRALIA

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Julian Freen-van Heeren

Amsterdam University Medical Centers

NETHERLANDS

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Paul G Thomas

Professor

Fred Hutch Cancer Center

UNITED STATES

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Justin Beardsley

Staff Specialist

University of Sydney

AUSTRALIA

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Peta Edler

University of Melbourne

AUSTRALIA

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Rebekah Street

University of Melbourne

AUSTRALIA

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Carolien van de Sandt

Research Interests

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Recent Grants

Articles (19)

The ageing immune system and its battle with viruses

Effect of Bacille Calmette-Guérin vaccination on immune responses to SARS-CoV-2 and COVID-19 vaccination.

Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan

Linking Epitope-Specific T-Cell Receptors to IFNγ Secretion Using Nanovial Technology.

Gradual changes within long-lived influenza virus-specific CD8&lt;sup&gt;+&lt;/sup&gt; T cells are associated with the loss of public TCR clonotypes in older adults.

Age and Latent Cytomegalovirus Infection Do Not Affect the Magnitude of De Novo SARS-CoV-2-Specific CD8&lt;sup&gt;+&lt;/sup&gt; T Cell Responses.

High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases

CD8+ T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age

T cell activation markers CD38 and HLA-DR indicative of non-seroconversion in anti-CD20-treated patients with multiple sclerosis following SARS-CoV-2 mRNA vaccination.

Robust immunity conferred by combining COVID-19 vaccine platforms in older adults

Methotrexate treatment hampers induction of vaccine-specific CD4 T cell responses in patients with IMID.

High glycaemic variability is associated with a reduced T cell cytokine response to influenza A virus

Selective pressure mediated by influenza virus M1<sub>58-66</sub> epitope-specific CD8<sup>+</sup>T cells promotes accumulation of extra-epitopic amino acid substitutions associated with viral resistance to these T cells.

Methodological optimisation of thymocyte isolation and cryopreservation of human thymus samples.

mRNA-1273 vaccinated inflammatory bowel disease patients receiving TNF inhibitors develop broad and robust SARS-CoV-2-specific CD8&lt;sup&gt;+&lt;/sup&gt; T cell responses.

Increasing HbA1c is associated with reduced CD8<sup>+</sup> T cell functionality in response to influenza virus in a TCR-dependent manner in individuals with diabetes mellitus.

Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations

CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity

Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan.

Collaborators (38)

Louise Rowntree

Dene Littler

Kristen Radford

Nicole La Gruta

Amy W Chung

David Lynn

Tobias Kollmann

Anastasia Minervina

THI HOANG OANH NGUYEN

Jennifer Habel

Sophie A Valkenburg

Julio Cesar Carrera Montoya

DirkJan Hijnen

Sander W. Tas

James A Triccas

Hayley McQuilten

Michael Gibbons

Caitlin Uren

Klaas P.J.M. van Gisbergen

Susan Phillipa Walker

Natalie Stevens

Jillian Lau

Wenna Lee

James McMahon

Patricia Illing

Benedikt Obermayer

Claudio Counoupas

Katie Nicol

Isabelle Jia Hui Foo

Branka Grubor-Bauk

Rob ter Heine

Miriam Anne Lynn

Katherine Kedzierska

Julian Freen-van Heeren

Paul G Thomas

Justin Beardsley

Peta Edler

Rebekah Street

Make your next move.

Gradual changes within long-lived influenza virus-specific CD8<sup>+</sup> T cells are associated with the loss of public TCR clonotypes in older adults.

Age and Latent Cytomegalovirus Infection Do Not Affect the Magnitude of De Novo SARS-CoV-2-Specific CD8<sup>+</sup> T Cell Responses.

mRNA-1273 vaccinated inflammatory bowel disease patients receiving TNF inhibitors develop broad and robust SARS-CoV-2-specific CD8<sup>+</sup> T cell responses.