Catherine Tooke

University of Bath

United Kingdom

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Articles (11)

Year:

2024

Year:

2024

Year:

2023

Year:

2022

Year:

2022

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2021

Year:

2021

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2021

Year:

2021

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2020

Year:

2020

Collaborators (10)

Pratul Agarwal

Oklahoma State University

UNITED STATES

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Jurgen Brem

University of Oxford

UNITED KINGDOM

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Francesco Luigi Gervasio

Full Professor

University of Geneva

SWITZERLAND

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James Spencer

UNITED KINGDOM

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Christopher T. Lohans

Queen's University

CANADA

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Christopher Schofield

University of Oxford

UNITED KINGDOM

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IN-SIK KIM

University of Chicago

UNITED STATES

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Michael Beer

University of Bristol

UNITED KINGDOM

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Adrian Mulholland

Professor at School of Physics

University of Bristol

UNITED KINGDOM

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Robert Bonomo

Case Western Reserve University

UNITED STATES

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Catherine Tooke

Research Interests

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Articles (11)

Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics

Dynamical responses predict a distal site that modulates activity in an antibiotic resistance enzyme

Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase

Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2

Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition

Allosteric communication in class a β-lactamases occurs via cooperative coupling of loop dynamics

An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography

Faropenem reacts with serine and metallo-β-lactamases to give multiple products.

Natural variants modify Klebsiella pneumonia carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance

Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance.

Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition

Collaborators (10)

Pratul Agarwal

Jurgen Brem

Francesco Luigi Gervasio

James Spencer

Christopher T. Lohans

Christopher Schofield

IN-SIK KIM

Michael Beer

Adrian Mulholland

Robert Bonomo

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