Christopher Schofield

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University of Oxford

United Kingdom

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Recent Grants

Grant: Close

Metabolomics for Bioscience Research

Open Date: 2018-04-30

Close Date: 2019-04-29

Grant: Close

RapidFire Enhancement of Mass Spectrometry Capability Across the Biosciences

Open Date: 2017-06-30

Close Date: 2018-06-29

Grant: Close

SAMRC Award - University of Oxford

Open Date: 2017-03-01

Close Date: 2019-02-28

Grant: Close

Defining the physiology and therapeutic potential of oxygenases as signalling enzymes.

Open Date: 2016-09-01

Close Date: 2022-09-01

Grant: Close

Accelerate CHNUK AMR discovery: Establishing joint China/UK training and research platforms enabling highthroughput fragment based inhibitor discovery

Open Date: 2016-06-30

Close Date: 2019-06-29

Articles (19)

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Collaborators (16)

Jurgen Brem

University of Oxford

UNITED KINGDOM

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James Spencer

UNITED KINGDOM

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Chris Schofield

University of Oxford

UNITED KINGDOM

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Catherine Tooke

University of Bath

UNITED KINGDOM

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Christopher T. Lohans

Queen's University

CANADA

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Giorgia Fiorini

Paul Scherrer Institut

SWITZERLAND

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Fraser A. Armstrong

UNITED KINGDOM

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Patrick Rabe

University of Oxford

UNITED KINGDOM

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Farnusch Kaschani

Head of Analytics Core Facility Essen

Universität Duisburg-Essen

GERMANY

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Fernanda Duarte

Associate Professor

University of Oxford

UNITED KINGDOM

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Renier A L van der Hoorn

University of Oxford

UNITED KINGDOM

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Michael Beer

University of Bristol

UNITED KINGDOM

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Gavin Screaton

Head Medical Sciences Division, Dean of Medicine

University of Oxford

UNITED KINGDOM

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Adrian Mulholland

Professor at School of Physics

University of Bristol

UNITED KINGDOM

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Pierre Buscaill

Lecturer in Plant Sciences

University of Bristol

UNITED KINGDOM

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Ana Sofia Fernandes Oliveira

University of Bristol

UNITED KINGDOM

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Christopher Schofield

Research Interests

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Recent Grants

Articles (19)

Biochemical and crystallographic studies of l,d-transpeptidase 2 from Mycobacterium tuberculosis with its natural monomer substrate

Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality

Substitution of 2-oxoglutarate alters reaction outcomes of the Pseudomonas savastanoi ethylene-forming enzyme

Effects of Clinical Mutations in the Second Coordination Sphere and Remote Regions on the Catalytic Mechanism of Non‐Heme Fe(II)/2‐Oxoglutarate‐Dependent Aspartyl Hydroxylase AspH

Fixing the Achilles Heel of Pfizer’s Paxlovid for COVID-19 Treatment

The Unique Role of the Second Coordination Sphere to Unlock and Control Catalysis in Nonheme Fe(II)/2-Oxoglutarate Histone Demethylase KDM2A

Biochemistry of the hypoxia-inducible factor hydroxylases

Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate

Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism

Electrochemical Nanoreactor Provides a Comprehensive View of Isocitrate Dehydrogenase Cancer‐drug Kinetics

Electrochemical Nanoreactor Provides a Comprehensive View of Isocitrate Dehydrogenase Cancer‐drug Kinetics

Photoaffinity labelling displacement assay using multiple recombinant protein domains

Structural basis for binding of the renal carcinoma target hypoxia‐inducible factor 2α to prolyl hydroxylase domain 2

Dynamical Nonequilibrium Molecular Dynamics Simulations Identify Allosteric Sites and Positions Associated with Drug Resistance in the SARS-CoV-2 Main Protease

Accelerating drug target inhibitor discovery with a deep generative foundation model

Optimized Synthesis of Indole Carboxylate Metallo-β-Lactamase Inhibitor EBL-3183

Differentiating Inhibition Selectivity and Binding Affinity of Isocitrate Dehydrogenase 1 Variant Inhibitors

Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase

Activity‐based proteomics uncovers suppressed hydrolases and a neo‐functionalised antibacterial enzyme at the plant–pathogen interface

Collaborators (16)

Jurgen Brem

James Spencer

Chris Schofield

Catherine Tooke

Christopher T. Lohans

Giorgia Fiorini

Fraser A. Armstrong

Patrick Rabe

Farnusch Kaschani

Fernanda Duarte

Renier A L van der Hoorn

Michael Beer

Gavin Screaton

Adrian Mulholland

Pierre Buscaill

Ana Sofia Fernandes Oliveira

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