Christiane Helene Berger-Schaffitzel

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Professor of Biochemistry

University of Bristol

United Kingdom

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About

Christiane Helene Berger-Schaffitzel is a Professor of Biochemistry at the University of Bristol, UK. Her research focuses on protein structure and function, with recent articles examining topics such as cryo-EM analysis of bacterial membrane proteins, RNA binding dynamics, and the development of new therapeutics for snakebite envenoming. She is also investigating the allosteric responses of SARS-CoV-2 spike variants, contributing to the understanding of molecular mechanisms in health and disease.

Recent Grants

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Megabody in vitro selection and engineering for cryo-EM structure analysis of FFAR1-bound lung fibrosis drugs to treat long COVID

Open Date: 2022-12-01

Close Date: 2023-11-01

Grant: Close

‘Up-frameshift protein interactions in translation termination and nonsense-mediated mRNA decay’

Open Date: 2022-04-01

Close Date: 2024-03-01

Grant: Close

Chinese Scholarship Council - University of BristoStructural and functional insights into nonsense-mediated mRNA decay

Open Date: 2021-09-01

Close Date: 2025-08-01

Grant: Close

Wellcome Trust Collaborator AwaNovel platforms to develop poly specifically-effective, safe, affordable and thermostable monoclonal camelid VHH nanobodies to treat snake venom-induced necrosis in India and sub-Saharan Africa

Open Date: 2021-04-01

Close Date: 2025-03-01

Grant: Close

ADDovenom: Novel Snakebite Therapy Platform of Unparalleled Efficacy, Safety and Affordability

Open Date: 2020-10-01

Close Date: 2024-09-01

Articles (19)

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Collaborators (18)

Kapil Gupta

University of Bristol

UNITED KINGDOM

Christiane Helene Berger-Schaffitzel

Research Interests

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About

Recent Grants

Articles (19)

Off-target structural insights: ArnA and AcrB in bacterial membrane-protein cryo-EM analysis

Dynamic RNA binding and unfolding by nonsense-mediated mRNA decay factor UPF2

Dual Proteomics Strategies to Dissect and Quantify the Components of Nine Medically Important African Snake Venoms

Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

Tuning VSV-G Expression Improves Baculovirus Integrity, Stability and Mammalian Cell Transduction Efficiency

An engineered baculoviral protein and DNA co-delivery system for CRISPR-based mammalian genome editing

Cryo-EM reveals binding of linoleic acid to SARS-CoV-2 spike glycoprotein, suggesting an antiviral treatment strategy

Nonsense-Mediated mRNA Decay Factor Functions in Human Health and Disease

ADDovenom: Thermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenoming

SARS-CoV-2 spike variants differ in their allosteric responses to linoleic acid

Highly efficient CRISPR-mediated large DNA docking and multiplexed prime editing using a single baculovirus

Molecular architecture of the autoinhibited kinesin-1 lambda particle

The free fatty acid–binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron

Pathogen-sugar interactions revealed by universal saturation transfer analysis

Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2

Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation

No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors

No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors

Collaborators (18)

Kapil Gupta

Mark Dodding

Andrew Giltrap

Quinton Loïc

Francesco Aulicino

Gavin Iain Welsh

Derek Woolfson

Tiong Kit Tan

Nicholas Casewell

Stefanie Menzies

Johannes Weijman

Erwin Ilegems

Philip Ward

Imre Berger

Christine Toelzer

Mark Dillingham

Ana Sofia Fernandes Oliveira

Timothy Satchwell

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