Nicholas Casewell

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Professor of Tropical Disease Biology

Liverpool School of Tropical Medicine

United Kingdom

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Recent Grants

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Discovery and early translation of small molecule toxin inhibitors for use as broadly effective, inexpensive, oral, prehospital snakebite treatments

Open Date: 2021-01-06

Close Date: 2025-01-05

Grant: Close

Multi-modal high resolution preclinical PET+SPECT+CT scanner

Open Date: 2018-07-01

Close Date: 2023-07-01

Grant: Close

Developing a universal antivenom to treat snake venom-induced consumption coagulopathy

Open Date: 2016-06-01

Close Date: 2021-05-31

Grant: Close

Origin, evolution and functional diversification of a chemical arsenal: venom in bony and cartilaginous fish

Open Date: 2014-02-01

Close Date: 2015-07-30

Grant: Close

Origin, evolution and functional diversification of a chemical arsenal: venom in bony and cartilaginous fish

Open Date: 2012-07-31

Close Date: 2014-01-31

Articles (18)

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2022

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2022

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2022

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2022

Collaborators (19)

Martine Smit

University of Amsterdam

NETHERLANDS

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Andreas Hougaard Laustsen

Technical University of Denmark

DENMARK

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Quinton Loïc

Professor

University of Liege

BELGIUM

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Bas van de Velde

Vrije Universiteit Amsterdam

NETHERLANDS

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Steven Hall

Lancaster University

UNITED KINGDOM

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Saer Samanipour

Assistant Professor

University of Amsterdam

NETHERLANDS

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Line Ledsgaard

Technical University of Denmark

DENMARK

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Rachel Clare

Academic, Senior Lecturer in Biochemistry

Edge Hill University

UNITED KINGDOM

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Nick Bergkamp

University of Amsterdam

NETHERLANDS

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Stefanie Menzies

University of Lancaster

UNITED KINGDOM

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Arif Arrahman

University of Amsterdam

NETHERLANDS

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Mohammed Zourob

SAUDI ARABIA

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Julien Slagboom

University of Amsterdam

NETHERLANDS

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Gabriel C. Lander

Professor

Scripps Research

UNITED STATES

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Imre Berger

Professor (Chair) and Director

University of Bristol

UNITED KINGDOM

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Dr. Cassandra Modahl

Lecturer

Liverpool School of Tropical Medicine

UNITED KINGDOM

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Gabriel Mazzucchelli

University of Liege

BELGIUM

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Christiane Helene Berger-Schaffitzel

Professor of Biochemistry

University of Bristol

UNITED KINGDOM

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John Baenziger

Professor

University of Ottawa

CANADA

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Nicholas Casewell

Research Interests

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Contact this professor

Recent Grants

Articles (18)

Aligning Post-Column ESI-MS, MALDI-MS, and Coagulation Bioassay Data of <i>Naja</i> spp., <i>Ophiophagus hannah</i>, and <i>Pseudonaja textillis</i> Venoms Chromatographically to Assess MALDI-MS and ESI-MS Complementarity with Correlation of Bioactive Toxins to Mass Spectrometric Data

Nanofractionation Analytics for Comparing MALDI-MS and ESI-MS Data of <i>Viperidae</i> Snake Venom Toxins

Importance of the Cysteine-Rich Domain of Snake Venom Prothrombin Activators: Insights Gained from Synthetic Neutralizing Antibodies

Investigating Snake-Venom-Induced Dermonecrosis and Inflammation Using an Ex Vivo Human Skin Model

Author Correction: The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors

Tissue damaging toxins in snake venoms: mechanisms of action, pathophysiology and treatment strategies

An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules

Monitoring Snake Venom-Induced Extracellular Matrix Degradation and Identifying Proteolytically Active Venom Toxins Using Fluorescently Labeled Substrates

Application of an Extracellular Matrix-Mimicking Fluorescent Polymer for the Detection of Proteolytic Venom Toxins

Metabolome-Based Classification of Snake Venoms by Bioinformatic Tools

Analytical Size Exclusion Chromatography Coupled with Mass Spectrometry in Parallel with High-Throughput Venomics and Bioassaying for Venom Profiling

Next-Generation Sequencing for Venomics: Application of Multi-Enzymatic Limited Digestion for Inventorying the Snake Venom Arsenal

ADDovenom: Thermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenoming

Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms

A Combined Bioassay and Nanofractionation Approach to Investigate the Anticoagulant Toxins of Mamba and Cobra Venoms and Their Inhibition by Varespladib

The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors.

Commercial Antivenoms Exert Broad Paraspecific Immunological Binding and In Vitro Inhibition of Medically Important Bothrops Pit Viper Venoms

Exploring the Utility of ssDNA Aptamers Directed against Snake Venom Toxins as New Therapeutics for Snakebite Envenoming

Collaborators (19)

Martine Smit

Andreas Hougaard Laustsen

Quinton Loïc

Bas van de Velde

Steven Hall

Saer Samanipour

Line Ledsgaard

Rachel Clare

Nick Bergkamp

Stefanie Menzies

Arif Arrahman

Mohammed Zourob

Julien Slagboom

Gabriel C. Lander

Imre Berger

Dr. Cassandra Modahl

Gabriel Mazzucchelli

Christiane Helene Berger-Schaffitzel

John Baenziger

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