Darren M. Griffith

Senior Lecturer

Royal College of Surgeons in Ireland

Ireland

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Darren M. Griffith is a Senior Lecturer at the Royal College of Surgeons in Ireland. His research areas include the development of novel metal complexes for therapeutic applications, particularly focusing on the synthesis and antibacterial activity of Ga(III) complexes, as well as the effects of platinum derivatives on cellular stress mechanisms. Recent articles authored by Dr. Griffith highlight the use of these metal complexes in combating respiratory infections and their potential roles in cancer treatment.

Articles (16)

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2025

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2024

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2024

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2024

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2024

A novel click-capable oxaliplatin mimic as a tool to study Pt( ii )-induced nucleolar stress.

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2023

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2023

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2023

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2023

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2022

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2022

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2021

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2021

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2020

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Victoria J. DeRose

University of Oregon

UNITED STATES

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M. Amelia Santos

Professor

Universidade de Lisboa Instituto Superior Técnico

PORTUGAL

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Brona Murphy

Health and Medical University

IRELAND

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Donal O'Shea

Professor, Head of Department

Royal College of Surgeons in Ireland

IRELAND

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Anthony P McHale

Professor of Medical Biotechnology

University of Ulster

UNITED KINGDOM

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Darren M. Griffith

Research Interests

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Articles (16)

Novel Platinum(II) Tetrazine Complex Capable of Live‐Cell IEDDA Reaction

Solution studies, synthesis and antibacterial activity of Ga(III) complexes with bis-kojate derivatives

Click-Capable Phenanthriplatin Derivatives as Tools to Study Pt(II)-Induced Nucleolar Stress

The activity of a Ga(III) catecholate complex against Aspergillus fumigatus in conditions mimicking cystic fibrosis lung and inhaled formulations for its pulmonary administration

Quantitative proteomic analysis reveals Ga(III) polypyridyl catecholate complexes disrupt Aspergillus fumigatus mitochondrial function.

Comparison of click-capable oxaliplatin and cisplatin derivatives to better understand Pt(<scp>ii</scp>)-induced nucleolar stress

First-in-class metallo-PROTAC as an effective degrader of select Pt-binding proteins

Oxaliplatin and its derivatives – An overview

Synthesis, characterisation and antibacterial activity of novel Ga(iii) polypyridyl catecholate complexes

Advances in the Design and Development of PROTAC-mediated HDAC Degradation

A <i>trans</i>-Pt(<scp>ii</scp>) hedgehog pathway inhibitor complex with cytotoxicity towards breast cancer stem cells and triple negative breast cancer cells

A single microbubble formulation carrying 5-fluorouridine, Irinotecan and oxaliplatin to enable FOLFIRINOX treatment of pancreatic and colon cancer using ultrasound targeted microbubble destruction

Medicinal chemistry and biomedical applications of bismuth-based compounds and nanoparticles

Synthesis and characterisation of a novel mono functionalisable Pt(IV) oxaliplatin-type complex and its peptide conjugate

Exploiting azide–alkyne click chemistry in the synthesis, tracking and targeting of platinum anticancer complexes

Synthesis and characterisation of Co(iii) complexes of N-formyl hydroxylamines and antibacterial activity of a Co(iii) peptide deformylase inhibitor complex

Collaborators (11)

Jinhui Gao

Graeme Sullivan

Olga Piskareva

Triona Ni Chonghaile

Daniel Alencar Rodrigues

Deirdre Fitzgerald Hughes

Victoria J. DeRose

M. Amelia Santos

Brona Murphy

Donal O'Shea

Anthony P McHale

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