Dmitry Veprintsev

Professor of Molecular and Cellular Pharmacology

University of Nottingham

United Kingdom

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Professor Dmitry Veprintsev serves in the Department of Molecular and Cellular Pharmacology at the University of Nottingham in the United Kingdom. His research focuses on a range of topics including cannabinoid receptors, regulatory autoantibodies, and drug delivery systems. Recent publications highlight advancements in understanding G protein coupling in CB2R and the development of novel assays for cannabinoid receptors.

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2025

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2020

Collaborators (23)

Roger Schibli

Prof. at ETH Zürich

ETH Zürich

SWITZERLAND

Dmitry Veprintsev

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Articles (20)

Structural basis of THC analog activity at the Cannabinoid 1 receptor

Multiple intramolecular triggers converge to preferential G protein coupling in the CB2R

A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay.

Advancing research on regulatory autoantibodies targeting GPCRs: Insights from the 5th international symposium

Profiling Allosteric Modulators of CB<sub>1</sub>R with an Allosteric Fluoroprobe

Agonist efficacy at the β2AR is driven by the faster association rate of the Gs protein

Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f

A Modified Cell-Penetrating Peptide Enhances Insulin and Oxytocin Delivery across an RPMI 2650 Nasal Epithelial Cell Barrier In Vitro

Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.

Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB<sub>1</sub>R)

Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors

Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells.

Kinetic analysis of endogenous β<sub>2</sub> -adrenoceptor-mediated cAMP GloSensor™ responses in HEK293 cells.

Exploring the kinetic selectivity of drugs targeting the β1‐adrenoceptor

Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe.

Michaelis-Menten quantification of ligand signalling bias applied to the promiscuous Vasopressin V2 receptor.

Combined docking and machine learning identify key molecular determinants of ligand pharmacological activity on β2 adrenoceptor

GPCR activation mechanisms across classes and macro/microscales

Functional solubilization of the β<sub>2</sub>-adrenoceptor using diisobutylene maleic acid

GPCR Activation States Induced by Nanobodies and Mini-G Proteins Compared by NMR Spectroscopy

Collaborators (23)

Roger Schibli

Franziska Sotzny

Christian Munk

Albert Kooistra

Poul Nissen

Sergio Barrondo

Alexander Hauser

Christos Iliopoulos_Tsoutsouvas

Thomas Boesen

M Teresa Grande

Michel Bouvier

Kevin Fone

David Onion

Rusan Catar

Javier Fernández-Ruiz

Bianca Plouffe

Michael Gajhede

David Gloriam

Jürg Gertsch

David R Poyner

Stephen Hill

Ning Ma

Steven Charlton

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