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Michael Gajhede

Københavns Universitet

Denmark

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Research Interests

Biochemistry

20%

Pharmaceutical Chemistry

40%

G Protein-coupled Receptor

30%

Ligand Design

30%

Chemical Biology

20%

Transporter Biology

20%

Peptide Chemistry

20%

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Articles14

Structural basis of THC analog activity at the Cannabinoid 1 receptor

Article Link

Year:

2025

Inhibition of ABCG2 by SCO-101 Enhances Chemotherapy Efficacy in Cancer

Article Link

Year:

2025

Small‐molecule positive allosteric modulation of homomeric kainate receptors <scp>GluK1</scp>‐3: development of screening assays and insight into <scp>GluK3</scp> structure

Article Link

Year:

2024

Structure-Guided Conformational Restriction Leading to High-Affinity, Selective, and Cell-Active Tetrahydroisoquinoline-Based Noncovalent Keap1-Nrf2 Inhibitors

Article Link

Year:

2024

Realizing integration in structural biology

Article Link

Year:

2023

Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors

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Year:

2023

Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery

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Year:

2022

Expression, purification and characterization of human proton-coupled oligopeptide transporter 1 hPEPT1

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Year:

2022

Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism

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Year:

2022

Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds

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Year:

2021

Reversal of ABCG2/BCRP-Mediated Multidrug Resistance by 5,3′,5′-Trihydroxy-3,6,7,4′-Tetramethoxyflavone Isolated from the Australian Desert Plant Eremophila galeata Chinnock

Article Link

Year:

2021

Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2

Article Link

Year:

2021

Lipid-bound ApoE3 self-assemble into elliptical disc-shaped particles

Article Link

Year:

2021

The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP

Article Link

Year:

2020

Collaborators33

jie zang

Københavns Universitet

DENMARK

Philip Biggin

University of Oxford

UNITED KINGDOM

Vincent Jaquet

Senior sientist/Head of READs unit

University of Geneva

SWITZERLAND

Poul Nissen

DENMARK

Francotte Pierre

University of Liege

BELGIUM

Osman Asghar Mirza

Københavns Universitet

DENMARK

Christos Iliopoulos_Tsoutsouvas

Research Assistant Professor

Northeastern University

UNITED STATES

Thomas Boesen

Aarhus University

DENMARK

Claus Oxvig

Professor

Aarhus University

DENMARK

Kenneth Kongstad

University of Copenhagen

DENMARK

Lasse Saaby

Københavns Universitet

DENMARK

Jan Stenvang

Associate Professor

University of Copenhagen

DENMARK

Tommy Johansen

Københavns Universitet

DENMARK

Maria Rafiq

Københavns Universitet

DENMARK

Nicolai Tidemand Johansen

Københavns Universitet

DENMARK

Roberta Brambilla

Assistant Professor

University of Miami School of Medicine

UNITED STATES

Frederik Vilhardt

Københavns Universitet

DENMARK

Karen Martinez

Københavns Universitet

DENMARK

Susan Semple

University of South Australia

AUSTRALIA

Jakob Hauge Mikkelsen

Aarhus University

DENMARK

Dilip Narayanan

Københavns Universitet

DENMARK

David Gloriam

Københavns Universitet

DENMARK

Anders Bach

Københavns Universitet

DENMARK

David Olagnier

Associate Professor (with tenure)

Aarhus University

DENMARK

Nicholas Michael Ian Taylor

Københavns Universitet

DENMARK

Jette S. Kastrup

DENMARK

Bala Krishna Prabhala

University of Southern Denmark

DENMARK

Annette Eva Langkilde

Københavns Universitet

DENMARK

Guillermo Montoya

DENMARK

Dmitry Veprintsev

Professor of Molecular and Cellular Pharmacology

University of Nottingham

UNITED KINGDOM

Lars Jakobsen Høj

Københavns Universitet

DENMARK

Anders Skov Kristensen

Associate professor

University of Copenhagen

DENMARK

Sara Marie Solbak

Københavns Universitet

DENMARK

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