Douglas Fowler

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Associate Professor

University of Washington

United States

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About

Douglas Fowler is an Associate Professor at the University of Washington, USA. His research focuses on the quantitative analysis of genetic variants, gene expression regulation, and the development of innovative assays for clinical variant interpretation. Recent articles highlight his work on multiplexed profiling, optogenetic systems, and the implications of variants of uncertain significance in genetics.

Recent Grants

Grant: Close

F-CAP: Functionalization of Variants in Clinically Actionable Pharmacogenes

Open Date: 2015-07-15

Close Date: 2018-06-30

Grant: Close

Large-Scale Methods for Assessing the Consequences of Mutations in Proteins

Open Date: 2014-09-01

Close Date: 2018-08-31

Grant: Close

Random Display of Gut Microflora Proteins to Analyze Obesity

Open Date: 2008-09-01

Close Date: 2011-08-31

Articles (18)

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2020

Collaborators (13)

richard james

Associate Professor

University of Washington

UNITED STATES

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Andre Berndt

Assistant Professor

University of Washington

UNITED STATES

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Chris Richardson

Assistant Professor

University of California, Santa Barbara

UNITED STATES

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Kenneth Matreyek

Assistant Professor

Case Western Reserve University

UNITED STATES

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Lea Starita

Research Assistant Professor

University of Washington

UNITED STATES

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Vincenzo Carnevale

Research Professor

Temple University

UNITED STATES

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Nobuhiko Tokuriki

Professor

The University of British Columbia

CANADA

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Frederick Roth

Professor

University of Toronto

CANADA

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Dustin Maly

Professor

UNITED STATES

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Willow Coyote-Maestas

Assistant Professor

University of California, San Francisco

UNITED STATES

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Shao-En Ong

University of Washington

UNITED STATES

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Anna Gloyn

University of Oxford

UNITED KINGDOM

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Daniel Schmidt

University of Minnesota

UNITED STATES

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Douglas Fowler

Research Interests

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About

Recent Grants

Articles (18)

Multiplexed assays of variant effect for clinical variant interpretation

The quantitative impact of 3′UTRs on gene expression

Image-based identification and isolation of micronucleated cells to dissect cellular consequences

Image-based identification and isolation of micronucleated cells to dissect cellular consequences

Calibration of variant effect predictors on genome-wide data masks heterogeneous performance across genes

Will variants of uncertain significance still exist in 2030?

Understanding genetic variants in context

Multiplexed profiling of intracellular protein abundance, activity, interactions and druggability with LABEL-seq

A chemically controlled Cas9 switch enables temporal modulation of diverse effectors

An Atlas of Variant Effects to understand the genome at nucleotide resolution

Molecular determinants of Hsp90 dependence of Src kinase revealed by deep mutational scanning

Optogenetic Microwell Array Screening System: A High-Throughput Engineering Platform for Genetically Encoded Fluorescent Indicators

Environmental selection and epistasis in an empirical phenotype–environment–fitness landscape

Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling

Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs

Parallel Chemoselective Profiling for Mapping Protein Structure

A Premalignant Cell-Based Model for Functionalization and Classification of PTEN Variants

Comprehensive exploration of the translocation, stability and substrate recognition requirements in VIM-2 lactamase

Collaborators (13)

richard james

Andre Berndt

Chris Richardson

Kenneth Matreyek

Lea Starita

Vincenzo Carnevale

Nobuhiko Tokuriki

Frederick Roth

Dustin Maly

Willow Coyote-Maestas

Shao-En Ong

Anna Gloyn

Daniel Schmidt

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