Eduard Jirkovsky

Assistant Professor, Postdoc

Faculty of Pharmacy, Charles University

Czech Republic

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About

Eduard Jirkovsky is an Assistant Professor and Postdoctoral researcher at the Faculty of Pharmacy, Charles University, Czech Republic. His research focuses on the effects of phenolic compounds and bisphenols on cardiovascular health, including their interaction with hormone receptors and their influence on vasodilation. Recent publications highlight the potential risks of bisphenol alternatives and innovative methods for drug screening, emphasizing his contributions to pharmacology and toxicology.

Articles (16)

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2025

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2024

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2024

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2024

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2024

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2023

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2023

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2022

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2022

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2021

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2021

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2021

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2021

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2021

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2020

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2020

Collaborators (11)

Lenka Javorská

University Hospital Hradec Králové

CZECH REPUBLIC

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Tomas Simunek

Professor, Vice-Dean

Charles University

CZECH REPUBLIC

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Lucija Peterlin Mašič

SLOVENIA

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Jana Pourová

Charles University in Prague

CZECH REPUBLIC

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marija sollner dolenc

University of Ljubljana

SLOVENIA

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Michal Kuty

University of South Bohemia

CZECH REPUBLIC

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Patrícia Dias

Ohio State University

UNITED STATES

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Přemysl Mladěnka

Charles University

CZECH REPUBLIC

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Radim Kučera

Charles University

CZECH REPUBLIC

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Caroline Austin

Professor

Newcastle University

UNITED KINGDOM

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Zuzana Lomozová

Assistant Professor

Faculty of Pharmacy, Charles University

CZECH REPUBLIC

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Eduard Jirkovsky

Research Interests

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About

Articles (16)

A novel bisphenol A alternative, DD-70, may negatively affect haemostasis through cyclooxygenase 1 inhibition

Small phenolic compounds as potential endocrine disruptors interacting with estrogen receptor alpha

3-methoxycatechol causes vasodilation likely via KV channels: ex vivo, in silico docking and in vivo study

The quercetin metabolite 4-methylcatechol causes vasodilation via voltage-gated potassium (KV) channels

The quercetin metabolite 4-methylcatechol causes vasodilation <i>via</i> voltage-gated potassium (K<sub>V</sub>) channels

A Complex Methodological Approach for the Screening of Efficient and Safe Cobalt Chelators

The effects of bisphenols on the cardiovascular system ex vivo and in vivo

Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up

The effects of bisphenols on the cardiovascular system

Vitamin C—Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination

Silymarin Dehydroflavonolignans Chelate Zinc and Partially Inhibit Alcohol Dehydrogenase

Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation

Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarin

Structure–Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions

Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery

Investigation of structure-activity relationships of dexrazoxane analogues reveals topoisomerase IIβ interaction as a prerequisite for effective protection against anthracycline cardiotoxicity

Collaborators (11)

Lenka Javorská

Tomas Simunek

Lucija Peterlin Mašič

Jana Pourová

marija sollner dolenc

Michal Kuty

Patrícia Dias

Přemysl Mladěnka

Radim Kučera

Caroline Austin

Zuzana Lomozová

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