Caroline Austin

Professor

Newcastle University

United Kingdom

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Professor Caroline Austin is a faculty member at Newcastle University in the United Kingdom. Her research focuses on the mechanisms of DNA topoisomerases, particularly TOP2B, and their roles in cellular processes and cancer therapies. Recent publications highlight her work on the effects of topoisomerase inhibitors and their implications for DNA damage and neural differentiation.

Articles (17)

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2025

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2020

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2020

Collaborators (9)

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Professor

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Professor, Vice-Dean

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CZECH REPUBLIC

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Katja Menger

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Maria Falkenberg

Professor

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Eduard Jirkovsky

Assistant Professor, Postdoc

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CZECH REPUBLIC

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Bert van den Berg

Professor of Membrane Protein Structural Biology

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UNITED KINGDOM

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Thomas J Nicholls

Newcastle University

UNITED KINGDOM

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Dan Kaufman

Professor

University of California, San Diego

UNITED STATES

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Johnny Lo

Senior Lecturer

Edith Cowan University

AUSTRALIA

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Caroline Austin

Research Interests

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About

Articles (17)

TOP2B is required for compartment strength changes upon retinoic acid treatment in SH-SY5Y cells

Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection

Myeloperoxidase inhibition protects bone marrow mononuclear cells from DNA damage induced by the TOP2 poison anti-cancer drug etoposide.

Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage.

To Break or Not to Break: The Role of TOP2B in Transcription.

DNA fragility at the KMT2A/MLL locus: insights from old and new technologies.

XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes

Two type I topoisomerases maintain DNA topology in human mitochondria

Disease-associated Mutations in Topoisomerase IIβ Result in Defective NK cells.

A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193

TOP2B Is Required to Maintain the Adrenergic Neural Phenotype and for ATRA-Induced Differentiation of SH-SY5Y Neuroblastoma Cells.

Structure–Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions

TOP2B's contributions to transcription.

Mechanisms to Repair Stalled Topoisomerase II-DNA Covalent Complexes.

A Role for VCP/p97 in the Processing of Drug-Stabilized TOP2-DNA Covalent Complexes.

Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta.

Small Molecule Inhibitors Confirm Ubiquitin-Dependent Removal of TOP2-DNA Covalent Complexes.

Collaborators (9)

Tim R. Blower

Tomas Simunek

Katja Menger

Maria Falkenberg

Eduard Jirkovsky

Bert van den Berg

Thomas J Nicholls

Dan Kaufman

Johnny Lo

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