Tomas Simunek

Professor, Vice-Dean

Charles University

Czech Republic

Research Interests

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Articles (8)

Year:

2023

Year:

2022

Year:

2022

Year:

2021

Year:

2021

Year:

2021

Year:

2021

Year:

2020

Collaborators (5)

ROBERTA PIACENTINI

Sapienza University of Rome

ITALY

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Eduard Jirkovsky

Assistant Professor, Postdoc

Faculty of Pharmacy, Charles University

CZECH REPUBLIC

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Alberto Macone

Associate Professor

Sapienza University of Rome

ITALY

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Jaroslav Roh

Associate Professor

Charles University, Faculty of Pharmacy in Hradec Kralove

CZECH REPUBLIC

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Caroline Austin

Professor

Newcastle University

UNITED KINGDOM

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Tomas Simunek

Research Interests

Contact this professor

Articles (8)

Hydrophobicity-enhanced ferritin nanoparticles for efficient encapsulation and targeted delivery of hydrophobic drugs to tumor cells

Examination of diverse iron-chelating agents for the protection of differentiated PC12 cells against oxidative injury induced by 6-hydroxydopamine and dopamine

Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up

Structure–Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions

Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation

Development of water-soluble prodrugs of the bisdioxopiperazine topoisomerase IIβ inhibitor ICRF-193 as potential cardioprotective agents against anthracycline cardiotoxicity

Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo

Investigation of structure-activity relationships of dexrazoxane analogues reveals topoisomerase IIβ interaction as a prerequisite for effective protection against anthracycline cardiotoxicity

Collaborators (5)

ROBERTA PIACENTINI

Eduard Jirkovsky

Alberto Macone

Jaroslav Roh

Caroline Austin

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