Francesco Doglietto
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Articles (19)
Year:
2025
Year:
2024
Year:
2024
Year:
2024
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2024
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2024
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2024
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2023
Year:
2023
Recently, advances in molecular biology and bioinformatics have allowed a more thorough understanding of tumorigenesis in aggressive PitNETs (pituitary neuroendocrine tumors) through the identification of specific essential genes, crucial molecular pathways, regulators, and effects of the tumoral microenvironment. Target therapies have been developed to cure oncology patients refractory to traditional treatments, introducing the concept of precision medicine. Preliminary data on PitNETs are derived from preclinical studies conducted on cell cultures, animal models, and a few case reports or small case series. This study comprehensively reviews the principal pathways involved in aggressive PitNETs, describing the potential target therapies. A search was conducted on Pubmed, Scopus, and Web of Science for English papers published between 1 January 2004, and 15 June 2023. 254 were selected, and the topics related to aggressive PitNETs were recorded and discussed in detail: epigenetic aspects, membrane proteins and receptors, metalloprotease, molecular pathways, PPRK, and the immune microenvironment. A comprehensive comprehension of the molecular mechanisms linked to PitNETs’ aggressiveness and invasiveness is crucial. Despite promising preliminary findings, additional research and clinical trials are necessary to confirm the indications and effectiveness of target therapies for PitNETs.
Year:
2023
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2023
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2023
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2023
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2022
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2022
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2021
Year:
2021
Year:
2021
Year:
2021
Collaborators (121)
Marian Vanhoeij
Vrije Universiteit Brussel
HERMAN SEHMBI
Western University
IOANNIS VALIOULIS
Associate Professor
Aristoteleio Panepistemio Thessalonikes
Jacobo Trebol
Profesor Asociado en Ciencias de la Salud
Universidad de Salamanca
Ladislao Cayetano Paniagua
Colorectal Surgery (unit chief currently)
Consorci Sanitari de Terrassa
Chikashi Takeda
Assistant professor
Kyoto University Hospital
Matteo Marro
Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino
Daniel Perez
Associate Professor of Surgery
University Medical Center Hamburg-Eppendorf
Paola Calleja Hermosa
Marqués de Valdecilla University Hospital
Davide Mattavelli
Associate Professor
University of Brescia
Liverana Lauretti
Università Cattolica del Sacro Cuore
Laura Sala
Fondazione IRCCS Istituto Nazionale dei Tumori
Marion Delpont
University of Montpellier
Pierpaolo Sileri
Full Professor of Surgery
Università Vita Salute San Raffaele
BALTASAR PÉREZ-SABORIDO
Profesor Asociado Ciencias de la Salud
Universidad de Valladolid
Ruth Christine Schäfer
-
Saam Tourani
University of Melbourne
Ahmed Elshabrawy
University of Texas Health Science Center at San Antonio
Nolan Bruce
Assistant Professor
UAMS Medical Center
Stefano Calza
Full Professor
University of Brescia
Daniel Jacobs-Tulleneers-Thevissen
Vrije Universiteit Brussel
Jiali Gao
University of Oxford
Ulrich Ronellenfitsch
Associate Professor of Surgery
-
Paola Zinser Peniche
University of Pittsburgh School of Medicine
Marisa Domingues Santos
Professora Associada
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar
Lucio De Maria
University of Brescia
Jasper Stijns
Vrije Universiteit Brussel
Alastair Morton
Nottingham University Hospitals NHS Trust
Roberto PALLINI
Associate Professor
Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia
Fanourios Georgiades
University of Cambridge
Nicholas Alexakis
Professor of Surgery
National and Kapodistrian University of Athens
Angelo Minucci
University of Padova
Aina Brunet
ENT, Head and Neck surgery Consultant
Hospital Universitari de Bellvitge
Ruth A Benson
Honorary Academic Clinical Lecturer
University of Birmingham
Shafaque Shaikh
Honorary Senior Clinical Lecturer
University of Aberdeen
Lucy Huppler
University of Bristol
Eiki Kanemaru
Lecturer
Yokohama City University Graduate School of Medicine
Manon Vounckx
Vrije Universiteit Brussel
Emma Howie
University of Edinburgh
NICCOLO' DADDI
Associate Professor
University of Bologna
Chang Woo Kim
Professor
Ajou University School of Medicine
Florestan J. Koll
University Hospital Frankfurt
Simona Gaudino
Agostino Gemelli University Polyclinic
Stephanie Hage
University of Chicago Medicine
Adam Frankel
University of Queensland
Luciana Sartore
University of Brescia
David C. Y. Tang
Honorary Lecturer
University of Otago
Stefania Angela Piccioni
Università degli Studi di Siena
Allison Brown
Assistant Clinical Professor
NYU Langone Medical Center
Marika Vezzoli
Assistant Professor of Biostatistics (MED/01)
University of Brescia
Susana Gonzalez Suarez
Universitat Autònoma de Barcelona (UAB)
Aimal Khan
Assistant Professor of Surgery
Vanderbilt University Medical Center
Pietro Luigi Poliani
University of Brescia
Rhea Darbari Kaul
Macquarie University
Kristin Colling
University of Minnesota
Emmanuel Katsogridakis
Lecturer in Vascular Surgery
University of Leicester
Shirley Jansen
University of Western Australia
Hilal A Al Sabti
-
Jeremy Wales
Karolinska University Hospital
Luigi Rolli
Fondazione IRCCS Istituto Nazionale dei Tumori
Shomik Sengupta
Professor of Surgery
MONASH UNIVERSITY
Tommaso Tartaglione
Reasercher - Aggregate Professor
Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia
Nicola Montano
Università Cattolica del Sacro Cuore
Amit Agrawal
Cambridge University Hospitals
Filippo Rapetto
University of Bristol
Neil Ryan
University of Bristol
Javier Aitor Zabala Lopez-Maturana
Profesor Agregado Otorrinolaringología
Euskal Herriko Unibertsitatea
Giuseppe Maria Della Pepa
Catholic University of Rome
Gonzalo Díaz Tapia
Associated Chief
Hospital Universitario Virgen del Rocío
Gemma Mancebo Moreno
ASSOCIATE PROFESSOR GINECOLOGY
Universitat Pompeu Fabra
Giuseppe SALAMONE
University of Palermo
George Kasotakis
Duke University
Rita Canotilho
Instituto Português de Oncologia do Porto
Sumir Gandhi
Associate Professor
New York University College of Dentistry
Edoardo Agosti
University of Brescia
Saurabh Sinha
University of Sheffield
Daniel Gero
University of Zurich
Marc Vallve-Bernal
Associate Professor
Universitat Rovira i Virgili
Rustom Manecksha
Clinical Associate Professor
Trinity College Dublin
Rubén Martín-Láez
Head of the department
Marqués de Valdecilla University Hospital
DAVIDE LOCATELLI
Chairman-Full professor
University of Insubria
Kathrin Patzer
-
Filipe Castro Borges
Universidade do Porto Faculdade de Medicina
Ahmad Ghazal
-
Ana Margarida Correia
Instituto Português de Oncologia do Porto
Rita Rezzani
Full Prof
University of Brescia
Filip Brzeszczyński
Medical University of Lodz
Kyoichi Tomoto
The Jikei University Hospital
Robert K. Parker
-
Pawel Miotla
Professor
Medical University of Lublin
Marco Caricato
Full Professor of Surgery
Università Campus Bio-Medico di Roma
Giuliana Germinario
University of Bologna
OLGA MATEO-SIERRA
Instituto de Investigación Sanitaria Gregorio Marañón
Christian Reiterer
Medical University of Vienna
CARLO GIORGIO GIUSSANI
Professor
University of Milano-Bicocca
JUAN-CARLOS GOMEZ-ROSADO
PROFESOR ASOCIADO ASCIS
Universidad de Málaga Facultad de Medicina
Maria P Ntalouka
Lecturer
-
Emanuele La Corte
Fondazione IRCCS Istituto Neurologico Carlo Besta
Michael Grechenig
Landeskrankenhaus Salzburg - Universitätsklinikum der Paracelsus Medizinischen Privatuniversität
Ángel Cilleruelo
-
Neel Doshi
-
Khaled Dajani
Assistant Teaching Professor
University of Alberta
Matthew Marshall-Webb
Queen Elizabeth Hospital
William Parry-Smith
Professor Obstetrics and Gynaecology
Keele University
Mateusz Zawadka
Assistant professor (adiunkt)
Medical University of Warsaw
Mohamed Otify
University of Liverpool
Ahmad Amir Kayali
Research Temporary Professional
Mayo Clinic Florida
Benjamin Hall
Brown University
Felix Aigner
Head
Graz University Hospital
Christian Praetorius
University Hospital Carl Gustav Carus
Pietro MORTINI
Full Professor of Neurosurgery
Vita-Salute San Raffaele University
Chiara Copelli
Associate Professor
University of Turin
Luca Ponchietti
Chief of Surgery
-
Sarah Rennie
Honorary Senior Lecturer
-
Sara Ramadan
Harvard University
marco Fontanella
Full Professor
University of Brescia
Ellen Van Eetvelde
Vrije Universiteit Brussel
Søren Kudsk‐Iversen
-
Maggie L. DiNome
Duke University School of Medicine
Achille Tarsitano
University of Bologna
Alessandro Fiorindi
University of Brescia
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