Bruno Pagano

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Full Professor

University of Naples Federico II

Italy

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About

Bruno Pagano is a Full Professor at the University of Naples Federico II in Italy. His research primarily focuses on G-quadruplex DNA structures and their implications in cancer biology. Recent articles reflect his work on ligand screening, smartphone-enabled nucleic acid analysis, and the development of anticancer agents targeting G-quadruplexes. He is also involved in exploring noncanonical nucleic acid structures for therapeutic applications.

Recent Grants

Grant: Close

Noncanonical DNA-binding proteins: from identification to next generation peptide-based anticancer therapeutics

Open Date: 2021-01-02

Close Date: 2024-04-01

Grant: Close

G-quadruplex-binding proteins and their functional relevance in human cancer cells

Open Date: 2016-01-01

Close Date: 2018-12-01

Grant: Close

G-quadruplex-forming aptamers for the therapy of prion diseases

Open Date: 2014-03-01

Close Date: 2017-03-01

Grant: Close

Telomere-targeting anticancer drugs

Open Date: 2011-12-01

Close Date: 2014-12-01

Articles (20)

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2022

Collaborators (12)

Jussara Amato

University of Naples Federico II

ITALY

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Vincenzo Abbate

King’s College London

UNITED KINGDOM

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Clelia Giannini

ITALY

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RITA MORIGI

Associate Professor

University of Bologna

ITALY

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federica santoro

University of Naples Federico II

ITALY

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University of Naples Federico II

ITALY

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Bruno Pagano

Research Interests

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About

Recent Grants

Articles (20)

Snap and detect: smartphone-enabled paper-based colorimetric tool for nucleic acid sequence-specific analysis

Design, Synthesis, and Anticancer Activity of Drug-like Iron Chelators/G-Quadruplex Binders as Synergic Dual Targeting Agents

Screening of G-quadruplex DNA ligands by fluorescence detection of peptide displacement

Identifying G-quadruplex-interacting proteins in cancer-related gene promoters

Expanding the Functions of KHSRP Protein: Insights into DNA G‐Quadruplex Binding

Development of a multi-targeted chemotherapeutic approach based on G-quadruplex stabilisation and carbonic anhydrase inhibition

Hindered intermolecular stacking of anti-parallel telomeric G-quadruplexes

Chemistry and Biology of Noncanonical Nucleic Acid Structures: From Physicochemical Properties to Therapeutic Applications

Discovery of 2,3-Diaminoindole Derivatives as a Novel Class of NOD Antagonists

Cytosine epigenetic modifications and conformational changes in G‐quadruplex DNA: An ultraviolet resonance Raman spectroscopy study

Hit identification of novel small molecules interfering with MALAT1 triplex by a structure‐based virtual screening

Targeting G-quadruplex motifs interferes with differentiation of adipose-derived mesenchymal stem cells.

G-quadruplexes in cancer-related gene promoters: from identification to therapeutic targeting

Printed Electrochemical Strip for the Detection of miRNA-29a: A Possible Biomarker Related to Alzheimer’s Disease

Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders.

Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells

Cyclic Triimidazoles as Stabilizers for Gene Promoter and Human Telomeric DNA G‐Quadruplexes

Combination of dl922-947 Oncolytic Adenovirus and G-Quadruplex Binders Uncovers Improved Antitumor Activity in Breast Cancer

Human inhalable antibody fragments neutralizing SARS-CoV-2 variants for COVID-19 therapy.

Conformational plasticity of DNA secondary structures: probing the conversion between i-motif and hairpin species by circular dichroism and ultraviolet resonance Raman spectroscopies

Collaborators (12)

Jussara Amato

Vincenzo Abbate

Clelia Giannini

RITA MORIGI

federica santoro

Giorgio Schiro

Bruno Catalanotti

stefano cinti

Giuseppe PORTELLA

Nunzia Iaccarino

Francesco Saverio Di Leva

Antonio Randazzo

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