Giuseppe Legname

Professor

Scuola Internazionale Superiore di Studi Avanzati

Italy

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Giuseppe Legname is a Professor at the Scuola Internazionale Superiore di Studi Avanzati in Italy. His research primarily focuses on prion diseases, neurodegeneration, and the molecular mechanisms underlying these conditions. Recent publications include studies on prion protein signaling, therapeutic strategies against prion diseases, and the interplay between tau pathology and prion proteins. He is dedicated to advancing the understanding of neurodegenerative diseases through innovative research methodologies.

Articles (15)

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2025

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2023

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2021

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2021

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2021

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2021

Collaborators (11)

Diego Muñoz-Torrero

Full Professor of Organic & Medicinal Chemistry

University of Barcelona

SPAIN

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Elena Adinolfi

Associate Professor

University of Ferrara

ITALY

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Anna Pegoraro

University of Ferrara

ITALY

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Maria Conte

ITALY

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Robert Kammerer

Friedrich-Loeffler-Institut Bundesforschungsinstitut für Tiergesundheit

GERMANY

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Maria Laura Bolognesi

ALMA MATER STUDIORUM UNIVERSITY OF BOLOGNA

ITALY

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Holly Garringer

Associate Research Professor

Indiana State University

UNITED STATES

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ANTONIO CHIARIELLO

University of Bologna

ITALY

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Ondrej Soukup

University Hospital Hradec Králové

CZECH REPUBLIC

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Fabio Moda

Assistant professor of Clinical Biochemistry and Clinical Molecular Biology

Università di Milano

ITALY

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Gabriele Giachin

University of Padua

ITALY

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Giuseppe Legname

Research Interests

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Articles (15)

The Role of Prion Protein in Reelin/Dab1 Signaling: Implications for Neurodegeneration

Copper coordination modulates prion conversion and infectivity in mammalian prion proteins

Different tau fibril types reduce prion level in chronically and de novo infected cells

Therapeutic strategies for identifying small molecules against prion diseases

Bifunctional carbazole derivatives for simultaneous therapy and fluorescence imaging in prion disease murine cell models

Detection of TDP-43 seeding activity in the olfactory mucosa from patients with frontotemporal dementia

Gerstmann–Sträussler–Scheinker Disease with F198S Mutation Induces Independent Tau and Prion Protein Pathologies in Bank Voles

The E3 Ubiquitin Ligase TRAF6 Interacts with the Cellular Prion Protein and Modulates Its Solubility and Recruitment to Cytoplasmic p62/SQSTM1-Positive Aggresome-Like Structures

Expression pattern of perilipins in human brain during aging and in Alzheimer's disease

Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer’s Disease

Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy

Astrocytes‐derived extracellular vesicles in motion at the neuron surface: Involvement of the prion protein

The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson’s Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells

Tackling prion diseases: a review of the patent landscape

The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils

Collaborators (11)

Diego Muñoz-Torrero

Elena Adinolfi

Anna Pegoraro

Maria Conte

Robert Kammerer

Maria Laura Bolognesi

Holly Garringer

ANTONIO CHIARIELLO

Ondrej Soukup

Fabio Moda

Gabriele Giachin

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