Hideki Aihara

Assistant/Associate Professor

University of Minnesota

United States

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About

Hideki Aihara is an Assistant Professor at the University of Minnesota, USA. His research primarily focuses on the structural biology of various proteins, including hydroxynitrile lyase, SARS-CoV-2 variants, and other viral inhibitors. Recent publications highlight his work on crystal structures and the biochemical analysis of molecular interactions involved in drug resistance and viral activities.

Articles (21)

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Collaborators (17)

Prokopios P. Argyris

UNITED STATES

Hideki Aihara

Research Interests

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About

Articles (21)

Crystal structure of a seven-substitution mutant of hydroxynitrile lyase from rubber tree

Crystal structures of 40- and 71-substitution variants of hydroxynitrile lyase from rubber tree

Structural basis for varying drug resistance of SARS-CoV-2 Mpro E166 variants

Human dystrophin tandem calponin homology actin-binding domain crystallized in a closed-state conformation

Crystal structure of the folded domains of Xrs2 from Saccharomyces cerevisiae

Discovery of Small-Molecule Orthopoxvirus Resolvase Inhibitors with Antiviral Activity

Structural basis for mouse receptor recognition by bat SARS2-like coronaviruses

A real-time biochemical assay for quantitative analyses of APOBEC-catalyzed DNA deamination

A compact stem-loop DNA aptamer targets a uracil-binding pocket in the SARS-CoV-2 nucleocapsid RNA-binding domain

Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein

Structural basis of sequence-specific cytosine deamination by double-stranded DNA deaminase toxin DddA

DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo

Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors

The crystal structure of the human smacovirus 1 Rep domain

Understanding ATP Binding to DosS Catalytic Domain with a Short ATP-Lid

Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variant

SARS-CoV-2 nsp14 Exoribonuclease Removes the Natural Antiviral 3′-Deoxy-3′,4′-didehydro-cytidine Nucleotide from RNA

4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease

Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN

X-ray Crystal Structures of Methane Monooxygenase Hydroxylase Complexes with Variants of Its Regulatory Component: Correlations with Altered Reaction Cycle Dynamics

New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition

Collaborators (17)

Prokopios P. Argyris

Daniel Harki

Rahul Banerjee

Nuri Temiz

Michael Carpenter

AHMED MAGDY KHALIL

Rachel Vogel

Ke Shi

Wei Zhang

Robert Geraghty

Darko Bosnakovski

Chengjin Ye

John Lipscomb

Michael Kyba

Micah Gearhart

David Largaespada

Wendy Gordon

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