Hiroaki Suga

Professor

University of Tokyo

Japan

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About

Hiroaki Suga is a Professor at The University of Tokyo, Japan. His research focuses on the design and synthesis of peptides, with recent contributions to areas such as peptide ligands, liquid-liquid phase separation, and ribosomal incorporation of nonproteinogenic amino acids. Suga's work emphasizes innovative methodologies for drug development and the modulation of protein interactions.

Articles (30)

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2025

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2023

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2023

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2023

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2023

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2023

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2023

Collaborators (19)

Sunbum Kwon

SOUTH KOREA

Hiroaki Suga

Research Interests

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About

Articles (30)

Ligand-Enabled Selective Coupling of MIDA Boronates to Dehydroalanine-Containing Peptides and Proteins

De Novo Peptides That Induce the Liquid–Liquid Phase Separation of α-Synuclein

Display selection of peptide ligands for helical aromatic foldamers

Promoting ribosomal incorporation of backbone-modifying nonproteinogenic amino acids into nascent peptides by ATP-binding cassette family-F proteins and EF-P

A super versatile flexizyme system with phenol esters for genetic code reprogramming

Direct Cellular Screening of Pd-Mediated Arylation of Cyclic Peptide Binders Targeting Ubiquitin Chains: Toward Modulating NEMO Liquid–Liquid Phase Separation

Rational design and selection of next-generation cyclotide drugs using the knotted cyclic peptide scaffold MCoTI-II

A versatile method of ribosomal synthesis of peptides containing long chain fatty acids at the N-terminus

Diversity Scale of Library Matters: Impact of mRNA Library Diversity Scales on the Discovery of Macrocyclic Peptides Targeting a Protein by the RaPID System

Development of selective nanomolar cyclic peptide ligands as GBA1 enzyme stabilisers

In Vitro Selection of Macrocyclic l-α/d-α/β/γ-Hybrid Peptides Targeting IFN-γ/IFNGR1 Protein–Protein Interaction

Fine-tuning the tRNA anticodon arm for multiple/consecutive incorporations of β-amino acids and analogs

Engineering tRNAs for the Ribosomal Translation of Non-proteinogenic Monomers

Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides

De Novo Discovery of Pseudo‐Natural Prenylated Macrocyclic Peptide Ligands

Mixed Stereochemistry Macrocycle Acts as a Helix-Stabilizing Peptide N-Cap

PlexinB1 Inactivation Reprograms Immune Cells in the Tumor Microenvironment, Inhibiting Breast Cancer Growth and Metastatic Dissemination

De Novo Discovery of Pseudo‐Natural Prenylated Macrocyclic Peptide Ligands

Protein Grafting Techniques: From Peptide Epitopes to Lasso‐Grafted Neobiologics

An anticodon-sensing T-boxzyme generates the elongator nonproteinogenic aminoacyl-tRNA in situ of a custom-made translation system for incorporation

Structural basis of tRNAPro acceptor stem recognition by a bacterial trans-editing domain

MET‐Activating Ubiquitin Multimers

MET‐Activating Ubiquitin Multimers

A comprehensive analysis of translational misdecoding pattern and its implication on genetic code evolution

Translation initiation with exotic amino acids using EF-P-responsive artificial initiator tRNA

Macrocyclic Peptides Closed by a Thioether–Bipyridyl Unit That Grants Cell Membrane Permeability

Drop-off-reinitiation at the amino termini of nascent peptides and its regulation by IF3, EF-G, and RRF

Combining Chemical Protein Synthesis and Random Nonstandard Peptides Integrated Discovery for Modulating Biological Processes

A RaPID Macrocyclic Peptide That Inhibits the Formation of α‐Synuclein Amyloid Fibrils

Two-Chain Mature Hepatocyte Growth Factor-Specific Positron Emission Tomography Imaging in Tumors Using 64Cu-Labeled HiP-8, a Nonstandard Macrocyclic Peptide Probe

Collaborators (19)

Sunbum Kwon

Alexandra Kuzmishin Nagy

Karin Musier-Forsyth

Takayuki Katoh

Yohei Miyanoiri

David De Sancho

Mark Foster

Joseph Rogers

Toru Sengoku

Katherine Stott

Tsutomu Suzuki

Alexander Vinogradov

Marta Artola

Thanh Binh Nguyen

Tatsuya Ikenoue

Giulia Franzolin

KANG JU LEE

Kunio MATSUMOTO

Yuki Goto

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