Marta Artola

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Assistant Professor

Leiden University

Netherlands

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About

Dr. Marta Artola is an Assistant Professor at Leiden University in the Netherlands. Her research focuses on RNA tertiary structures, lysosomal glucocerebrosidase, and the role of glucosylated cholesterol in atherosclerosis. Additionally, she investigates glycosidase profiling and enzyme stabilization through innovative ligand design. Dr. Artola's recent publications highlight her contributions to the fields of biochemistry and molecular biology.

Recent Grants

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FtsZ protein as a therapeutic target for the development of new antibacterial agents

Open Date: 2010-10-01

Close Date: 2014-10-01

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Collaborators (23)

Carme Rovira

Professor at University of Barcelona

University of Barcelona

SPAIN

Marta Artola

Research Interests

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About

Recent Grants

Articles (20)

Cultured Macrophage Models for the Investigation of Lysosomal Glucocerebrosidase and Gaucher Disease

Glucosylated cholesterol accumulates in atherosclerotic lesions and impacts macrophage immune response

High-throughput competitive binding assay for targeting RNA tertiary structures with small molecules: application to pseudoknots and G-quadruplexes

Precision Activity‐Based α‐Amylase Probes for Dissection and Annotation of Linear and Branched‐Chain Starch‐Degrading Enzymes

Precision Activity‐Based α‐Amylase Probes for Dissection and Annotation of Linear and Branched‐Chain Starch‐Degrading Enzymes

Development of selective nanomolar cyclic peptide ligands as GBA1 enzyme stabilisers

From Mechanism-Based Retaining Glycosidase Inhibitors to Activity-Based Glycosidase Profiling

Structure-guided design of C3-branched swainsonine as potent and selective human Golgi α-mannosidase (GMII) inhibitor

Synthesis and Biological Evaluation of Deoxycyclophellitols as Human Retaining β‐Glucosidase Inhibitors

6-O-alkyl 4-methylumbelliferyl-β-D-glucosides as selective substrates for GBA1 in the discovery of glycosylated sterols

Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish

1,6-epi-Cyclophellitol cyclosulfamidate is a bona fide lysosomal α-glucosidase stabilizer for the treatment of Pompe disease

Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery

Xylose‐Configured Cyclophellitols as Selective Inhibitors for Glucocerebrosidase

Fabry Disease: Molecular Basis, Pathophysiology, Diagnostics and Potential Therapeutic Directions

Human glucocerebrosidase mediates formation of xylosyl-cholesterol by beta-xylosidase and transxylosidase reactions

Cysteine Nucleophiles in Glycosidase Catalysis: Application of a Covalent β‐l‐Arabinofuranosidase Inhibitor

Cysteine Nucleophiles in Glycosidase Catalysis: Application of a Covalent β‐l‐Arabinofuranosidase Inhibitor

Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents

Activity-Based Protein Profiling of Retaining α-Amylases in Complex Biological Samples

Collaborators (23)

Carme Rovira

Jorge Ferreira

R. Fernando Martínez

Henar Vázquez-Villa

Johannes Aerts

Rolf Boot

Christian Tudorache

Gideon Davies

Mar Martin-Fontecha

Inês Ferreira

Takatoshi Arakawa

Hiroaki Suga

Sybrin Schröder

MARIA L. LOPEZ-RODRIGUEZ

Liang Wu

Annemarie H. Meijer

Zachary Armstrong

Otilia Vieira

Maria Soares

Quélia Ribeiro

Paul Geurink

Gerlind Sulzenbacher

Qin Su

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