Hiroki Akiba

助教 / Assistant Professor

Kyoto University

Japan

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About

Hiroki Akiba is an Assistant Professor at Kyoto University in Japan. His research primarily focuses on the development of innovative antibodies and their applications in cancer diagnostics and therapeutics, as evidenced by his recent publications on biparatopic antibodies and their mechanisms. He is also involved in studies related to photocatalytic methods for biomolecule labeling and advanced imaging techniques for gastric cancer.

Articles (12)

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2025

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2025

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2025

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2023

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2023

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2023

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2020

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2020

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2020

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2020

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Hiroki Akiba

Research Interests

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Articles (12)

Visible light-mediated photocatalytic coupling between tetrazoles and carboxylic acids for biomolecule labelling

Conversion of an agonistic anti-TNFR2 biparatopic antibody into an antagonist by insertion of peptide linkers into the hinge region

Generation of antagonistic biparatopic anti-CD30 antibody from an agonistic antibody by precise epitope determination and utilization of structural characteristics of CD30 molecule

A Proximity‐Induced Fluorogenic Reaction Triggered by Antibody–Antigen Interactions with Adjacent Epitopes

A Proximity‐Induced Fluorogenic Reaction Triggered by Antibody–Antigen Interactions with Adjacent Epitopes

Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection

64Cu-labeled minibody D2101 visualizes CDH17-positive gastric cancer xenografts with short waiting time

<sup>111</sup>In-labeled anti-cadherin17 antibody D2101 has potential as a noninvasive imaging probe for diagnosing gastric cancer and lymph-node metastasis

Development and activities, including immunocomplex formation, of biparatopic antibodies and alternative scaffold proteins

Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain

GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 ab

Generation of biparatopic antibody through two-step targeting of fragment antibodies on antigen using SpyTag and SpyCatcher

Collaborators (5)

Kosuke Ogata

Haruhiko Kamada

Yasuhiro Abe

Norihito Arichi

Kouhei Tsumoto

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