Jacob Piehler

Professor of Biophysics

University of Osnabrück

Germany

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About

Jacob Piehler is a Professor of Biophysics at Osnabrück University, Germany. His research focuses on biophysical mechanisms in cellular processes, particularly related to signaling pathways involving cytokine receptors and their role in diseases. Recent articles include studies on the dynamics of endosomal recycling and the structural insights into cytokine receptor complexes.

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2021

Collaborators (17)

Claudio De Virgilio

Full Professor

University of Fribourg

SWITZERLAND

Jacob Piehler

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Articles (20)

Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration

Glia trigger endocytic clearance of axonal proteins to promote rodent myelination

Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling

A strategy to design protein-based antagonists against type I cytokine receptors.

Promiscuous Janus kinase binding to cytokine receptors modulates signaling efficiencies and contributes to cytokine pleiotropy.

Correlative single-molecule and structured illumination microscopy of fast dynamics at the plasma membrane.

Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency.

Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches.

Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis

Mechanism of receptor assembly via the pleiotropic adipokine Leptin.

Dissociation of beta2m from MHC class I Triggers formation of Noncovalent, transient heavy chain dimers

Four-color single-molecule imaging with engineered tags resolves the molecular architecture of signaling complexes in the plasma membrane

The HOPS tethering complex is required to maintain signaling endosome identity and TORC1 activity

Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization

Biofunctionalization of carbon nanotubes for reversible site-specific protein immobilization

Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses

Diffraction-Unlimited Photomanipulation at the Plasma Membrane via Specifically Targeted Upconversion Nanoparticles

Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action

Flexible open conformation of the AP-3 complex explains its role in cargo recruitment at the Golgi

Collaborators (17)

Claudio De Virgilio

Sebastian Springer

Florian Fröhlich

Charlotte Uetrecht

Johannes Preiner

Changjiang You

MARTIN LOPEZ-GARCIA

Raffaele Nicastro

Daniel Thomas

Naotaka Tsutsumi

Markus Haase

Janine-Denise Kopicki

Nathanael Caveney

Julian Weghuber

Pramod Nair

Carola Meyer

Martin Schwill

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