James Ankrum

Associate Professor

Iowa State University

United States

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James Ankrum is an Associate Professor at the University of Iowa, USA. His research primarily focuses on immunomodulation, specifically the interactions between mesenchymal stem cells and macrophages, as well as the effects of environmental toxins such as polychlorinated biphenyls on metabolic processes. Recent articles highlight his work on the immunological impact of palmitate and its role in macrophage polarization, along with the analysis of scaffold-free adipose spheroids and adiponectin's influence on fibroblast conversion.

Articles (17)

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2025

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2022

Collaborators (8)

Jan Nolta

Professor, Director of the Stem Cell Program

University of California, Davis

UNITED STATES

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Aloysius Klingelhutz

Professor

Iowa State University

UNITED STATES

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Karen English

Professor

Maynooth University

IRELAND

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Jacob Herrmann

Assistant Professor

The University of Iowa

UNITED STATES

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Francesca E Duncan

UNITED STATES

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Francoise Gourronc

Iowa State University

UNITED STATES

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Prianka H. Hashim

University of Michigan

UNITED STATES

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Andrew Hogan

Associate Professor

National University of Ireland, Maynooth

IRELAND

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James Ankrum

Research Interests

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Articles (17)

Palmitate enhances MSC immunomodulation of human macrophages via the ceramide/CCL2 axis in vitro

Polychlorinated biphenyls induce immunometabolic switch of antiinflammatory macrophages toward an inflammatory phenotype

Mesenchymal stromal cells can block palmitate training of macrophages via cyclooxygenase-2 and interleukin-1 receptor antagonist

Development and analysis of scaffold-free adipose spheroids

The Impact of High Adiposity on Endometrial Progesterone Response and Metallothionein Regulation

Three-Dimensionally Printed Agarose Micromold Supports Scaffold-Free Mouse Ex Vivo Follicle Growth, Ovulation, and Luteinization

Upregulation of fatty acid synthesis genes in the livers of adolescent female rats caused by inhalation exposure to PCB52 (2,2′,5,5′-Tetrachlorobiphenyl)

Native adiponectin plays a role in the adipocyte-mediated conversion of fibroblasts to myofibroblasts

Efferocytosis of viable versus heat-inactivated MSC induces human monocytes to distinct immunosuppressive phenotypes

Toxicity Impacts on Human Adipose Mesenchymal Stem/Stromal Cells Acutely Exposed to Aroclor and Non-Aroclor Mixtures of Polychlorinated Biphenyl

Improved MSC Minimal Criteria to Maximize Patient Safety: A Call to Embrace Tissue Factor and Hemocompatibility Assessment of MSC Products

Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126).

Transcriptome sequencing of 3,3',4,4',5-Pentachlorobiphenyl (PCB126)-treated human preadipocytes demonstrates progressive changes in pathways associated with inflammation and diabetes.

Native Adiponectin Plays a Role in the Adipocyte Mediated Conversion of Fibroblasts to Myofibroblasts

Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3 ' ,4,4 ' ,5-Pentachlorobiphenyl (PCB126)

Toxicity impacts on human adipose MSCs acutely exposed to Aroclor and non-Aroclor mixtures of PCBs

Chemomechanically antifibrotic stromal cells

Collaborators (8)

Jan Nolta

Aloysius Klingelhutz

Karen English

Jacob Herrmann

Francesca E Duncan

Francoise Gourronc

Prianka H. Hashim

Andrew Hogan

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