Karen English

Professor

Maynooth University

Ireland

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Professor Karen English is a faculty member at Maynooth University in Ireland. Her research primarily focuses on immunomodulation, macrophage polarization, and the therapeutic mechanisms of mesenchymal stromal cells (MSCs). Recent publications explore the interactions between MSCs and human macrophages, particularly in relation to inflammatory diseases and allergy. Her work contributes significantly to understanding and developing treatments for chronic inflammatory conditions.

Karen English

Research Interests

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Articles (20)

Palmitate enhances MSC immunomodulation of human macrophages via the ceramide/CCL2 axis in vitro

Polychlorinated biphenyls induce immunometabolic switch of antiinflammatory macrophages toward an inflammatory phenotype

Mesenchymal stromal cells can block palmitate training of macrophages via cyclooxygenase-2 and interleukin-1 receptor antagonist

Mesenchymal stromal cells dampen trained immunity in house dust mite-primed macrophages expressing human macrophage migration inhibitory factor polymorphism

The human MIF polymorphism CATT7 enhances pro‐inflammatory macrophage polarization in a clinically relevant model of allergic airway inflammation

MAC attack: MSCs and macrophages join forces against chronic lung infection

Carbon monoxide licensing of MSCs enhances their efficacy through autophagy-mediated miRNA mechanisms

The MSC-EV-microRNAome: A Perspective on Therapeutic Mechanisms of Action in Sepsis and ARDS

Blockade of MIF biological activity ameliorates house dust mite‐induced allergic airway inflammation in humanized MIF mice

Apoptotic MSCs, COX2/PGE2 and clinical efficacy in Crohn fistula

Human macrophage migration inhibitory factor potentiates mesenchymal stromal cell efficacy in a clinically relevant model of allergic asthma

Mucosal associated invariant T cells are altered in patients with Hidradenitis Suppurativa and contribute to the inflammatory milieu.

Translating MSC Therapy in the Age of Obesity.

Helminth antigens modulate human PBMCs, attenuating disease progression in a humanised mouse model of graft versus host disease

Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges.

Cyclosporine A and IFNγ licencing enhances human mesenchymal stromal cell potency in a humanised mouse model of acute graft versus host disease

The Inflammatory Lung Microenvironment; a Key Mediator in MSC Licensing

IFN-γ and PPARδ Influence the Efficacy and Retention of Multipotent Adult Progenitor Cells in Graft vs Host Disease

Research Progress on Strategies that can Enhance the Therapeutic Benefits of Mesenchymal Stromal Cells in Respiratory Diseases With a Specific Focus on Acute Respiratory Distress Syndrome and Other Inflammatory Lung Diseases.

Healthy <i>versus</i> inflamed lung environments differentially effect MSCs.

Collaborators (11)

James Ankrum

Anna Krasnodembskaya

Anthony Ting

Seamas Donnelly

Aloysius Klingelhutz

Eoin McNamee

Bernard Mahon

Michelle E. Armstrong

Sara Rolandsson Enes

Andrew Hogan

Eyal Amiel

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