James Hougland

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Professor

Syracuse University

United States

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Recent Grants

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Defining the Molecular Architecture for Transmembrane Acylation by a Membrane Bound O-Acyltransferase

Open Date: 2019-09-01

Close Date: 2022-08-31

Grant: Close

Targeting ghrelin acylation for control of glucose homeostasis

Open Date: 2016-01-01

Close Date: 2018-12-31

Grant: Close

Evolution of Novel Farnesyltransferase Activity

Open Date: 2006-08-01

Close Date: 2009-01-31

Articles (15)

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2024

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2023

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2022

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2022

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2021

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2021

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2021

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2021

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2020

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2020

Collaborators (7)

Walter Schmidt

University of Georgia

UNITED STATES

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Mehdi Farokhnia

National Institutes of Health

UNITED STATES

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Carston R. Wagner

University of Minnesota

UNITED STATES

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Yuk Sham

University of Minnesota

UNITED STATES

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Brendan Tunstall

Assistant Professor

University of Tennessee Health Science Center

UNITED STATES

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Katarzyna Justyna

Assistant Professor at the Institute of Organic Chemistry

Lodz University of Technology

POLAND

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Mark D. Distefano

UNITED STATES

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James Hougland

Research Interests

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Recent Grants

Articles (15)

Library Screening, In Vivo Confirmation, and Structural and Bioinformatic Analysis of Pentapeptide Sequences as Substrates for Protein Farnesyltransferase

Targeted genetic and small molecule disruption of N-Ras CaaX cleavage alters its localization and oncogenic potential

Initial pharmacological characterization of a major hydroxy metabolite of PF-5190457: inverse agonist activity of PF-6870961 at the ghrelin receptor

Combined Computational–Biochemical Approach Offers an Accelerated Path to Membrane Protein Solubilization

Synthesis, Enzymatic Peptide Incorporation, and Applications of Diazirine-Containing Isoprenoid Diphosphate Analogues

Cellular Uptake of a Fluorescent Ligand Reveals Ghrelin O-Acyltransferase Interacts with Extracellular Peptides and Exhibits Unexpected Localization for a Secretory Pathway Enzyme

A closer look at alcohol‐induced changes in the ghrelin system: novel insights from preclinical and clinical data

Photoswitchable Isoprenoid Lipids Enable Optical Control of Peptide Lipidation

Temperature-Responsive Nano-Biomaterials from Genetically Encoded Farnesylated Disordered Proteins

MALDI-MS Analysis of Peptide Libraries Expands the Scope of Substrates for Farnesyltransferase

Ghrelin octanoylation by ghrelin O -acyltransferase: protein acylation impacting metabolic and neuroendocrine signalling

Engineering reversible cell–cell interactions using enzymatically lipidated chemically self-assembled nanorings

Engineering reversible cell-cell interactions using enzymatically lipidated chemically self-assembled nanorings

An overview of ghrelin O-acyltransferase inhibitors: a literature and patent review for 2010-2019

Protein Farnesyltransferase Catalyzes Unanticipated Farnesylation and Geranylgeranylation of Shortened Target Sequences

Collaborators (7)

Walter Schmidt

Mehdi Farokhnia

Carston R. Wagner

Yuk Sham

Brendan Tunstall

Katarzyna Justyna

Mark D. Distefano

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