Jan Wijnholds

Associate Prof

Leiden University Medical Center

Netherlands

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About

Jan Wijnholds is an Associate Professor at Leiden University Medical Center in the Netherlands. His research focuses on retinal therapies, including miRNA applications and gene augmentation strategies for retinal ciliopathies. Recent publications highlight his work with human iPSC-derived retinal organoids and AAV-mediated gene therapy approaches. He continues to explore innovative treatments to enhance patient quality of life in relation to retinal dystrophies.

Articles (18)

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2025

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2020

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2020

Collaborators (14)

Stylianos Michalakis

University Hospital, LMU Munich

GERMANY

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Perry Moerland

Assistant professor

Amsterdam University Medical Centers, location AMC

NETHERLANDS

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CJF Boon

Professor of Clinical Ophthalmogenetics

Amsterdam University Medical Centers

NETHERLANDS

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Raman Das

The University of Manchester

UNITED KINGDOM

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Elvir Becirovic

University of Zurich

SWITZERLAND

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Stefanie Fenske

Ludwig-Maximilians-Universität München

GERMANY

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Johanna H Meijer

Professor

Leiden University Medical Center

NETHERLANDS

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Andrew Furley

University of Sheffield

UNITED KINGDOM

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Tom DeBoer

Associate professor

Leiden University Medical Center

NETHERLANDS

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Kavitha Chinnaiya

University of Sheffield

UNITED KINGDOM

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Lucie P. Pellissier

FRANCE

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Manuel Goncalves

Associate professor

Leiden University

NETHERLANDS

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Kate Storey

Academic, Professor of Neural Development

University of Dundee

UNITED KINGDOM

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Celso Henrique Alves

University of Coimbra

PORTUGAL

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Jan Wijnholds

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Articles (18)

miR-429 RNA therapy as generic strategy to protect against photoreceptor loss

Conventional and Tropism-Modified High-Capacity Adenoviral Vectors Exhibit Similar Transduction Profiles in Human iPSC-Derived Retinal Organoids

Retinal Ciliopathies and Potential Gene Therapies: A Focus on Human iPSC-Derived Organoid Models

mRNA trans-splicing dual AAV vectors for (epi)genome editing and gene therapy.

CRB1 is required for recycling by RAB11A+ vesicles in human retinal organoids.

Characterization and AAV-mediated CRB gene augmentation in human-derived CRB1KO and CRB1KOCRB2+/− retinal organoids

Quality of life in patients with <i>CRB1</i>‐associated retinal dystrophies: A longitudinal study

AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype

AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype

Sleep Deprivation Does not Change the Flash Electroretinogram in Wild-type and Opn4<sup>−/−</sup>Gnat1<sup>−/−</sup> Mice

AAV-CRB2 protects against vision loss in an inducible CRB1 retinitis pigmentosa mouse model

Defining inclusion criteria and endpoints for clinical trials: a prospective cross-sectional study in CRB1-associated retinal dystrophies.

CLINICAL CHARACTERISTICS AND NATURAL HISTORY OF RHO-ASSOCIATED RETINITIS PIGMENTOSA: A Long-Term Follow-Up Study.

RPGR-associated dystrophies: Clinical, genetic, and histopathological features

Novel Therapeutic Approaches for the Treatment of Retinal Degenerative Diseases: Focus on CRISPR/Cas-Based Gene Editing

Crumbs2 mediates ventricular layer remodelling to form the spinal cord central canal

Research Models and Gene Augmentation Therapy for <i>CRB1</i> Retinal Dystrophies.

Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays.

Collaborators (14)

Stylianos Michalakis

Perry Moerland

CJF Boon

Raman Das

Elvir Becirovic

Stefanie Fenske

Johanna H Meijer

Andrew Furley

Tom DeBoer

Kavitha Chinnaiya

Lucie P. Pellissier

Manuel Goncalves

Kate Storey

Celso Henrique Alves

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