Jeffrey Brault

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Associate Professor

Indiana University School of Medicine

United States

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Jeffrey Brault is an Associate Professor at Indiana University School of Medicine in the United States. His research interests encompass purine metabolism, insulin resistance, and muscle performance, with recent articles focusing on signaling pathways in prostate cancer, mechanisms of testicular infertility, and the role of dietary nitrates in muscle health. He investigates cellular energetics and the physiological responses of skeletal muscle, contributing to the understanding of various metabolic conditions.

Recent Grants

Grant: Close

Brault R01 11.21.16

Open Date: 2017-07-24

Close Date: 2022-06-30

Grant: Close

A therapeutic approach to muscle wasting by limiting protein breakdown

Open Date: 2007-08-01

Close Date: 2010-07-31

Articles (14)

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2024

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2021

Collaborators (12)

John Scott

Lab Head, Neurometabolism

Monash Institute of Pharmaceutical Sciences

AUSTRALIA

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Andrew R. Coggan

UNITED STATES

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Danial Ahwazi

Københavns Universitet

DENMARK

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Atul Deshmukh

Københavns Universitet

DENMARK

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Christopher Lewis

Københavns Universitet

DENMARK

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Ronald C Wek

Indiana University School of Medicine

UNITED STATES

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P. Bryant Chase

Assoc/Full Professor

Florida State University

UNITED STATES

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Julien Ochala

Københavns Universitet

DENMARK

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Alex Addinsall

Københavns Universitet

DENMARK

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Chris Kargl

University of Pittsburgh

UNITED STATES

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Conchita Fraguas Bringas

Københavns Universitet

DENMARK

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Jon Oakhill

Australian Catholic University

AUSTRALIA

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Jeffrey Brault

Research Interests

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Recent Grants

Articles (14)

A Barth Syndrome Patient-Derived <i>D75H</i> Point Mutation in <i>TAFAZZIN</i> Drives Progressive Cardiomyopathy in Mice

Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes

Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer

The Loss of Tafazzin Transacetylase Activity Is Sufficient to Drive Testicular Infertility

CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle

Creatine Kinase Equilibration and ΔGATP over an Extended Range of Physiological Conditions: Implications for Cellular Energetics, Signaling, and Muscle Performance

Beeting atrophy: dietary nitrate to protect the powerhouse of the cell?

Hypoxia Resistance Is an Inherent Phenotype of the Mouse Flexor Digitorum Brevis Skeletal Muscle

Peroxisome proliferator-activated receptor γ coactivator 1-α overexpression improves angiogenic signalling potential of skeletal muscle-derived extracellular vesicles

Skeletal muscle contraction kinetics and AMPK responses are modulated by the adenine nucleotide degrading enzyme AMPD1

Intrinsic adaptations in OXPHOS power output and reduced tumorigenicity characterize doxorubicin resistant ovarian cancer cells

Liquid chromatography method for simultaneous quantification of ATP and its degradation products compatible with both UV–Vis and mass spectrometry

Insulin Resistance Is Not Sustained Following Denervation in Glycolytic Skeletal Muscle

AMP deamination is sufficient to replicate an atrophy-like metabolic phenotype in skeletal muscle

Collaborators (12)

John Scott

Andrew R. Coggan

Danial Ahwazi

Atul Deshmukh

Christopher Lewis

Ronald C Wek

P. Bryant Chase

Julien Ochala

Alex Addinsall

Chris Kargl

Conchita Fraguas Bringas

Jon Oakhill

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