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Jernej Ule

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Director of Dementia Research Institute at King's

King’s College London

United Kingdom

Research Interests

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Recent Grants

Grant: Open

Disentangling the diverse forms of collective protein homeostasis in neuronal condensates

Open Date: 2026-09-01

Close Date: 2034-08-31

Grant: Open

Characterising the regulatory mechanisms at decoy 5’ splice sites

Open Date: 2024-03-01

Close Date: 2027-02-28

Grant: Close

Neuronal Tau-RNA interactions in health and disease

Open Date: 2024-01-10

Close Date: 2026-01-09

Grant: Open

Context-dependent RNA regulation and its application in auto-gating therapeutics for brain disorders

Open Date: 2024-01-09

Close Date: 2032-01-08

Grant: Close

Therapeutic modulation of feedback loops to counteract the molecular TDP-43 pathogenesis

Open Date: 2022-12-01

Close Date: 2025-11-30

Articles (20)

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Collaborators (27)

Rui Galao

King’s College London

UNITED KINGDOM

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Maria Victoria Botuyan

Mayo Clinic

UNITED STATES

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James Shorter

UNITED STATES

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Alice Y. Ting

Stanford University

UNITED STATES

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Mark Skehel

Head

The Francis Crick Institute

UNITED KINGDOM

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Randall Johnson

Karolinska Institutet

SWEDEN

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Giampietro Schiavo

Professor

University College London

UNITED KINGDOM

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Piera Pasinelli

Professor & Director, Weinberg ALS Center

Thomas Jefferson University

UNITED STATES

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Emanuele Buratti

Contracted Professor- Transcriptomic Course

Università degli Studi di Torino

ITALY

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Christopher Donnelly

Associate Professor

University of Texas Southwestern Medical Center

UNITED STATES

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Matthew Keuss

Senior Research Fellow

University College London

UNITED KINGDOM

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Nicolas Fawzi

Brown University

UNITED STATES

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Ben E. Black

Professor

University of Pennsylvania

UNITED STATES

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Chad Swanson

King’s College London

UNITED KINGDOM

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Julien Gagneur

Group leader

Technical University of Munich

GERMANY

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Yi-Wei Chang

Associate Professor

University of Pennsylvania

UNITED STATES

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Peter Hill

King’s College London

UNITED KINGDOM

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Mario Poljak

SLOVENIA

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Emil Gustavsson

Assistant Research Professor

University of Cambridge

UNITED KINGDOM

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Harry David Wilson

King’s College London

UNITED KINGDOM

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Sarah Kargbo-Hill

Assistant Professor

University of Michigan

UNITED STATES

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Hazuki Takahashi

Research Scientist

Yokohama National University

JAPAN

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James Briscoe

The Francis Crick Institute

UNITED KINGDOM

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Songyi Lee

Assistant Professor

DGIST

SOUTH KOREA

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Miha Modic

Tenure-track Professor and Head of Department for Genomics and Development

Karlsruhe Institute of Technology

GERMANY

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Nicholas Luscombe

Professor

Okinawa Institute of Science and Technology Graduate University

JAPAN

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Maïwen Caudron-Herger

Group Leader

Deutsches Krebsforschungszentrum

GERMANY

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Jernej Ule

Research Interests

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Recent Grants

Articles (20)

LAMP1 and LAMP2A localise to axonal organelles with distinct motility dynamics and partially overlapping molecular signatures in human neurons

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Integrative profiling of condensation-prone RNAs during early development

The long isoform of ZAP coordinates multiple enzymes to mediate complete decay of target transcripts

Meta-unstable mRNAs in activated CD8+ T cells are defined by interlinked AU-rich elements and m6A mRNA methylation.

nf-core/cutandrun: A Nextflow pipeline for the analysis of CUT&RUN, CUT&Tag and TIP-seq datasets

Widespread 3′UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites (vol 22, 254, 2024)

Alu-mediated RNA duplexes are associated with widespread exon skipping across primate transcriptomes

From computational models of the splicing code to regulatory mechanisms and therapeutic implications

Collective homeostasis of condensation-prone proteins via their mRNAs

CAR-SPLASH identifies nascent pre-mRNA structures implicated in kinetic coupling and alternative splicing

Axonal RNA localization is essential for long-term memory

Author Correction: TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A.

Poised PABP–RNA hubs implement signal-dependent mRNA decay in development

Widespread 3′UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites

Creation of de novo cryptic splicing for ALS and FTD precision medicine

NEAT1 modulates the TIRR/53BP1 complex to maintain genome integrity

The challenges of investigating RNA function

The FXR1 network acts as a signaling scaffold for actomyosin remodeling

The impact of IDR phosphorylation on the RNA binding profiles of proteins

Collaborators (27)

Rui Galao

Maria Victoria Botuyan

James Shorter

Alice Y. Ting

Mark Skehel

Randall Johnson

Giampietro Schiavo

Piera Pasinelli

Emanuele Buratti

Christopher Donnelly

Matthew Keuss

Nicolas Fawzi

Ben E. Black

Chad Swanson

Julien Gagneur

Yi-Wei Chang

Peter Hill

Mario Poljak

Emil Gustavsson

Harry David Wilson

Sarah Kargbo-Hill

Hazuki Takahashi

James Briscoe

Songyi Lee

Miha Modic

Nicholas Luscombe

Maïwen Caudron-Herger

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