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Jiri Jiracek

Group leader

Institute of Organic Chemistry and Biochemistry

Czech Republic

Research Interests

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Professors in Biochemistry

Articles (12)

Year:

2026

Year:

2025

Year:

2024

Year:

2024

Year:

2024

Year:

2024

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Collaborators (9)

Kamil Parkan

Associate professors

University of Chemistry and Technology

CZECH REPUBLIC

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Michaela Tencerova

Group leader

Czech Academy of Sciences

CZECH REPUBLIC

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Ales Marek

Institute of Organic Chemistry and Biochemistry

CZECH REPUBLIC

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Irena Selicharová

senior researcher

Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry

CZECH REPUBLIC

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Lenka Zakova

Institute of Organic Chemistry and Biochemistry

CZECH REPUBLIC

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Jakub Kaminsky

Senior researcher

Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry

CZECH REPUBLIC

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Milan Kožíšek

Institute of Organic Chemistry and Biochemistry

CZECH REPUBLIC

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Jakub Zýka

University of Chemistry and Technology

CZECH REPUBLIC

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Andrzej Marek Brzozowski

Professor

University of York

UNITED KINGDOM

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Jiri Jiracek

Research Interests

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Articles (12)

An engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling

Design of Potent Mannose‐6‐Phosphate Derivatives as Ligands for CI‐M6P/IGF2R Using Fluorescence Polarization Assay

IGF2: Overlooked Peptide from Insulin-Like Family of Hormones with Great Therapeutical Potential

A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression

Combinatorial Libraries of Bipodal Binders of the Insulin Receptor

Insulin–Dendrimer Nanocomplex for Multi‐Day Glucose‐Responsive Therapy in Mice and Swine (Adv. Mater. 5/2024)

Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2

Modulation of the antagonistic properties of an insulin mimetic peptide by disulfide bridge modifications

Insulin receptor Arg717 and IGF-1 receptor Arg704 play a key role in ligand binding and in receptor activation

Targeting the insulin receptor with hormone and peptide dimers

Recombinant Insulin-Like Growth Factor 1 Dimers: Receptor Binding Affinities and Activation Abilities

Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2

Collaborators (9)

Kamil Parkan

Michaela Tencerova

Ales Marek

Irena Selicharová

Lenka Zakova

Jakub Kaminsky

Milan Kožíšek

Jakub Zýka

Andrzej Marek Brzozowski

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