Jonathan Heeney

Has grant

Professor of Comparative Pathology

University of Cambridge

United Kingdom

Research Interests

Explore related searches

Professors in United Kingdom Professors in Immunology Immunology professors in United Kingdom

Contact this professor

Get a free first email built on one of their papers, ready for you to edit and send yourself.

About

Professor Jonathan Heeney is a faculty member at the University of Cambridge in the United Kingdom. His research primarily focuses on comparative pathology, with recent publications exploring topics related to COVID-19, including immune aging, neuropsychiatric symptoms, and vaccine responses. His work also investigates viral pathogenesis and the relationship between primate lentiviruses and their potential to cross into humans.

Recent Grants

Grant: Open

mRNA delivered multi-antigen broadly protective Betacoronavirus vaccine

Open Date: 2022-03-01

Close Date: 2027-03-01

Grant: Close

Investigation of proven vaccine breakthrough by SARS-CoV-2 variants in established UK healthcare worker cohorts: SIREN consortium & PITCH Plus Pathway

Open Date: 2021-08-12

Close Date: 2023-02-12

Grant: Close

Immunogenicity of a Trivalent Vaccine Candidate against Lassa Fever, Ebola, and Marburg virus

Open Date: 2020-09-30

Close Date: 2024-03-31

Grant: Close

Development of a Universal Influenza Vaccine using Digital Immune Optimising Synthetic Vaccine Antigens (DIOSynVax)

Open Date: 2019-08-01

Close Date: 2023-12-01

Grant: Close

Lassa outbreak response: early intervention and community response capacity in Ondo, Edo and Ebonyi states, Nigeria

Open Date: 2019-07-01

Close Date: 2021-01-01

Articles (20)

Year:

2024

Year:

2024

Year:

2024

Year:

2024

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2023

The antiviral restriction factor, tetherin, blocks the release of several different families of enveloped viruses, including the Coronaviridae. Tetherin is an interferon‐induced protein that forms parallel homodimers between the host cell and viral particles, linking viruses to the surface of infected cells and inhibiting their release. We demonstrate that SARS‐CoV‐2 infection causes tetherin downregulation and that tetherin depletion from cells enhances SARS‐CoV‐2 viral titres. We investigate the potential viral proteins involved in abrogating tetherin function and find that SARS‐CoV‐2 ORF3a reduces tetherin localisation within biosynthetic organelles where Coronaviruses bud, and increases tetherin localisation to late endocytic organelles via reduced retrograde recycling. We also find that expression of Spike protein causes a reduction in cellular tetherin levels. Our results confirm that tetherin acts as a host restriction factor for SARS‐CoV‐2 and highlight the multiple distinct mechanisms by which SARS‐CoV‐2 subverts tetherin function.

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Collaborators (67)

Bronwen Connolly

The Queen's University Belfast

UNITED KINGDOM

Jonathan Heeney

Research Interests

Explore related searches

Contact this professor

About

Recent Grants

Articles (20)

Effect of second booster vaccinations and prior infection against SARS-CoV-2 in the UK SIREN healthcare worker cohort

Accelarated immune ageing is associated with COVID-19 disease severity.

Replicative fitness and pathogenicity of primate lentiviruses in lymphoid tissue, primary human and chimpanzee cells: relation to possible jumps to humans

Immunological insights into COVID-19 in Southern Nigeria.

SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

Glycan masking of a non-neutralising epitope enhances neutralising antibodies targeting the RBD of SARS-CoV-2 and its variants

Differential T-cell and antibody responses induced by mRNA versus adenoviral vectored COVID-19 vaccines in patients with immunodeficiencies.

Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study.

A research and development (R&D) roadmap for broadly protective coronavirus vaccines: A pandemic preparedness strategy.

Tetherin antagonism by <scp>SARS‐CoV</scp>‐2 <scp>ORF3a</scp> and spike protein enhances virus release

Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury.

Long COVID research: an update from the PHOSP-COVID Scientific Summit.

A computationally designed antigen eliciting broad humoral responses against SARS-CoV-2 and related sarbecoviruses

Immune imprinting and next-generation coronavirus vaccines

Inhibition of the lectin pathway of complement activation reduces Acute Respiratory Distress Syndrome severity in a mouse model of SARS-CoV-2 infection.

Influenza A (N1-N9) and Influenza B (B/Victoria and B/Yamagata) Neuraminidase Pseudotypes as Tools for Pandemic Preparedness and Improved Influenza Vaccine Design

Humoral and cellular immune responses to Lassa fever virus in Lassa fever survivors and their exposed contacts in Southern Nigeria.

Vaccination and protective immunity to SARS-CoV-2 omicron variants in people with immunodeficiencies.

Antibody correlates of protection from SARS-CoV-2 reinfection prior to vaccination: A nested case-control within the SIREN study.

Increased Prevalence of Lassa Fever Virus-Positive Rodents and Diversity of Infected Species Found during Human Lassa Fever Epidemics in Nigeria.

Collaborators (67)

Bronwen Connolly

Benedikt Asbach

Susanna Dunachie

Roger Thompson

Davies Adeloye

Paul Moss

Antonia Ho

James R Edgar

Brian Willett

John R. Petrie

Louise MacGillivray

Hamish McAuley

Cherie Armour

Pilar Rivera-Ortega

Luke Daines

Anthony Rostron

Petros Andrikopoulos

Julie Whitney

Jon Hazeldine

Michael Howell

Laura Merson

Tassos Grammatikopoulos

Gerry McCann

Charlotte Bolton

Nigel Temperton

Ryan Thwaites

Timothy Wallis

Michael Gibbons

Salman Siddiqui

Karen Piper Hanley

Effrossyni Gkrania-Klotsas

Tao Dong

Rachel Upthegrove

Vicky Kamwa

Joby Cole

Lauren Robinson

Manish Patel

Catherine Atkin

Neil Greening

Eric J Arts

Michelle Holland

David Crossman

Lesley Price

Stephen P. McAdoo

Abigail Severn

Gareth E Jones

Manish Pareek

Edward Monk

Joanna Porter

Kelly Andreia Sullivan da Costa

Alex Horsley

Matthew Broome