João Vinagre
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Recent Grants
Grant: Close
Portable Microfluidic system for fast molecular diagnostics of Stroke
Open Date: 2023-03-10
Close Date: 2024-09-09
Grant: Close
The sound of cells: An acoustic platform aiming towards biophysical cell fingerprints for label-free precision medicine
Open Date: 2023-03-06
Close Date: 2026-03-05
Grant: Close
CTRL+ALT+CEL: how ATRX controls an alternative program in the ß-cell
Open Date: 2022-01-01
Close Date: 2024-12-31
Grant: Close
Pancreatic neuroendocrine tumors: ATRX and DAXX correlation with clinical-pathological data and telomere length
Open Date: 2021-01-01
Close Date: 2021-12-01
Grant: Close
CEEC Junior Researcher
Open Date: 2019-05-01
Close Date: 2025-04-30
Articles (11)
MicroRNAs (miRNAs) act as negative regulators for protein-coding gene expression impacting cell proliferation, differentiation, and survival. These miRNAs are frequently dysregulated in cancer and constitute classes of blood-based biomarkers useful for cancer detection and prognosis definition. In thyroid cancer (TC), the miRNA biogenesis pathway plays a pivotal role in thyroid gland formation, ensuring proper follicle development and hormone production. Several alterations in the miRNA biogenesis genes are reported as a causality for miRNA dysregulation. Mutations in microprocessor component genes are linked to an increased risk of developing TC; in particular, a recurrent mutation affecting DGCR8, the E518K. In this review, we explore these novel findings and resume the current state-of-the-art in miRNAs in thyroid carcinomas.
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2024
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2023
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2023
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2023
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2023
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2022
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2022
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2022
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2022
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2021
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2020
Collaborators (11)
Carla Oliveira
University of Porto
Valdemar Maximo
Assistant Professor
Faculty of Medicine of the University of Porto
Lia Rodrigues
Professora Assistente Convidada
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa
Paula Soares
Professora Associada
Universidade do Porto Faculdade de Medicina
José Cabeçadas
Head of department
Instituto Português de Oncologia do Porto
Jorge Lima
Vice-Director and Head of R&D
IPATIMUP, Institute of Pathology and Molecular Immunology of the University of Porto
Mafalda Sousa
BioImage Analyst
Instituto de Biologia Molecular e Celular
Maria de Fátima Gärtner
Full professor
University of Porto
Rui Martins
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
José Manuel Lopes
Chief Pathologist
Centro Hospitalar Universitário do Porto
Ana Pestana
Junior Professor
Charité - Universitätsmedizin Berlin
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