Joost Smolders

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Neurologist/ Associate Professor

Erasmus MC

Netherlands

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About

Dr. Joost Smolders is an Associate Professor at Erasmus MC in the Netherlands. His research primarily focuses on multiple sclerosis and includes the study of immune cell dynamics, biomarkers for disease progression, and treatment strategies. Recent publications discuss the roles of T cells in central nervous system autoimmunity and the implications of serum biomarkers in disease activity monitoring.

Recent Grants

Grant: Close

Aanstelling arts-assistent neurologie voor opleidingsprogramma binnen de MS neurologie in de context van de PROUD-studie (Predicting the Outcome of a Demyelinating event)

Open Date: 2021-01-01

Close Date: 2025-01-01

Grant: Close

Understanding the disease course of MS across the lifespan

Open Date: 2020-01-01

Close Date: 2024-01-01

Grant: Close

Tissue resident memory T cells in MS

Open Date: 2018-01-01

Close Date: 2023-01-01

Grant: Close

Vitamin D in multiple sclerosis

Open Date: 2016-01-01

Close Date:

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Collaborators (15)

Finn Sellebjerg

Professor

Copenhagen University Hospital

DENMARK

Joost Smolders

Research Interests

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About

Recent Grants

Articles (20)

Perturbances in Both Circulating B and CD4+ T Cells Discriminate Multiple Sclerosis from Other Central Nervous System Autoimmune Diseases

Reliability of serum neurofilament light and glial fibrillary acidic protein for detecting disease activity upon discontinuation of first-line disease-modifying therapy in stable multiple sclerosis (DOT-MS)

Tissue-resident memory CD4+ T cells infiltrate the CNS in progressive multiple sclerosis and contribute to chronic autoimmunity in mice.

Acquisition of residency programs by T cells entering the human brain

Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis

Multiple sclerosis severity variant in DYSF-ZNF638 locus associates with neuronal loss and inflammation

Strong association with remote EBV infection in children with MS as opposed to other acquired demyelinating disorders

Multifaceted Biomarkers Suggest a Similar Profile of CNS Pathology in Relapsing and Progressive MS

Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis and neuromyelitis optica spectrum disorder - recommendations from ECTRIMS and the EBMT

Aggressive treatment of early acute focal inflammatory activity to extend the window for BTK inhibition in multiple sclerosis

Real‐world challenges in the diagnosis of primary progressive multiple sclerosis

Epstein–Barr virus and genetic risk variants as determinants of T-bet+ B cell-driven autoimmune diseases

Health-economic benefits of anti-CD20 treatments in relapsing multiple sclerosis estimated using a treatment-sequence model

Locus for severity implicates CNS resilience in progression of multiple sclerosis.

Selective emergence of antibody-secreting cells in the multiple sclerosis brain

Multiple sclerosis risk variants influence the peripheral B‐cell compartment early in life in the general population

Multiple sclerosis risk variants influence the peripheral B-cell compartment early in life in the general population

Should anti-CD20 be used as an immune reconstitution therapy?

Editorial: Environmental factors influencing the immune functions during multiple sclerosis

Ultrastructural Axon–Myelin Unit Alterations in Multiple Sclerosis Correlate with Inflammation

Collaborators (15)

Finn Sellebjerg

Karim Kreft

Sergio E Baranzini

Maria Ban

Maarten Kole

Katayoun Alikhani

Christine Stadelmann

Marzena Pedrini

Janna Saarela

Helle Bach Søndergaard

Adil Harroud

Jörg Hamann

Michael Khalil

Torben Ruhwedel

Allan Kermode

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