Jörg Hamann

Netherlands

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Articles (10)

Year:

2023

GPR56/ ADGRG1 is an adhesion G protein‐coupled receptor connected to brain development, haematopoiesis, male fertility, and tumorigenesis. Nevertheless, expression of GPR56 is not restricted to developmental processes. Studies over the last years have demonstrated a marked presence of GPR56 in human cytotoxic NK and T cells. Expression of GPR56 in these cells is driven by the transcription factor HOBIT, corresponds with the production of cytolytic mediators and the presence of CX 3 CR1 and CD57, indicates a state of terminal differentiation and cellular exhaustion, and disappears upon cellular activation. Functional studies indicate that GPR56 regulates cell migration and effector functions and thereby acts as an inhibitory immune checkpoint. We here discuss the current state of knowledge regarding GPR56 in cytotoxic lymphocytes.

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2023

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2022

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2022

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2022

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2021

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2021

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2021

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2021

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2021

Collaborators (54)

Mario Caceres

Associate Professor

University of Barcelona

SPAIN

Jörg Hamann

Research Interests

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Articles (10)

Ultrastructural Axon–Myelin Unit Alterations in Multiple Sclerosis Correlate with Inflammation

The adhesion G protein‐coupled receptor GPR56/<i>ADGRG1</i> in cytotoxic lymphocytes

Association between dexamethasone treatment and the host response in COVID-19 patients admitted to the general ward

T-cell surveillance of the human brain in health and multiple sclerosis

Programmed Cell Death Protein 1–Positive CD8+ T Cells in Multiple Sclerosis

Mapping the human genetic architecture of COVID-19.

Autoantibodies neutralizing type I IFNs are present in <b>~</b>4% of uninfected individuals over 70 years old and account for <b>~</b>20% of COVID-19 deaths.

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.

The Inhibitory Receptor GPR56 (Adgrg1) Is Specifically Expressed by Tissue-Resident Memory T Cells in Mice but Dispensable for Their Differentiation and Function In Vivo

Multiple Targets for Oxysterols in Their Regulation of the Immune System

Collaborators (54)

Mario Caceres

Elżbieta Kaja

Edith Nutescu

Yoshihiro Eriguchi

Christophe PARIZOT

Justine Rudkin

Yohei Mikami

John Mackrill

Metz Christine

Martin Tolstrup

Mattia Cordioli

Sarah Earle

Hyeongseok Jeong

Maarten Kole

David Ellinghaus

Mari Kaunisto

Clíona Ní Cheallaigh

Shawneequa Callier

Alessio Gerussi

Nirmal Vadgama

Petros Andrikopoulos

Christine Stadelmann

Joost Smolders

David Morrison

Ida Moltke

Barbara Shih

Pierre Vabres

Minttu Marttila

Leif G. Hanitsch

Takaki Asano

Mathias Van Singer

Kate H. Moore

Marielle LEBRUN

Sandor Szalma

James Scriven

Ali AMARA

laurent meertens

Elena Carnero-Montoro

Matthew O'Shea

Joseph Grzymski

Martijn Beudel

Torben Ruhwedel

Angie Fawkes

Julia Kraft

Emma Connolly

Olivier Hugli

qiang pan-hammarstrom

CLAUDIO ANGELINI

Giorgio CASARI

Mark Peters

Eleftherios Michailidis

Hyo-Jung Lee

David Gomez-Cabrero

Seiamak Bahram

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