Karl Gruber

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Full professor

Graz University of Technology

Austria

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About

Karl Gruber is a Full Professor at the University of Graz, Austria. His research focuses on enzyme structure and function, biocatalysis, and the development of antiviral therapies, as evidenced by his recent publications on Old Yellow Enzymes and drug discovery methods. Additionally, he explores advanced techniques such as deep-mutational scanning to enhance scientific outcomes. His work integrates computational methods with biochemical research to address contemporary challenges in the life sciences.

Recent Grants

Grant: Close

The family of berberine bridge enzymes in plants

Open Date: 2015-01-01

Close Date: 2018-01-01

Grant: Close

Structure based enzyme annotation, identification and design

Open Date: 2015-01-01

Close Date: 2019-01-01

Grant: Close

Active Site Repurposing – computational design of new enzyme functionalities by emulating nature

Open Date: 2014-01-01

Close Date: 2017-01-01

Grant: Close

Structure-function studies on signal transduction in photoactivatable cyclaes

Open Date: 2014-01-01

Close Date: 2017-01-01

Grant: Close

Phosphatidylserine decarboxylase 1 of the yeast

Open Date: 2013-01-01

Close Date: 2016-01-01

Articles (18)

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2025

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2024

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2024

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2022

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2022

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2021

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2021

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2021

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2021

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2020

Professor

Graz University of Technology

AUSTRIA

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Helmut Bergler

Graz University of Technology

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Robert Kourist

Univ.-Prof. at Graz University of Technology

Graz University of Technology

AUSTRIA

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Lena Parigger

Graz University of Technology

AUSTRIA

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Gustav Oberdorfer

Graz University of Technology (90000)

AUSTRIA

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Karl Gruber

Research Interests

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About

Recent Grants

Articles (18)

Structure, Oligomerization, and Thermal Stability of a Recently Discovered Old Yellow Enzyme

Asymmetric Synthesis of Chiral 2-Cyclohexenones with Quaternary Stereocenters via Ene-Reductase Catalyzed Desymmetrization of 2,5-Cyclohexadienones

Flattening the curve-How to get better results with small deep-mutational-scanning datasets

Old Yellow Enzymes as Oxime Reductases: New Variants by Substrate‐Based Enzyme Engineering

Deciphering the Unconventional Reduction of C═N Bonds by Old Yellow Enzymes Using QM/MM

CavitOmiX Drug Discovery: Engineering Antivirals with Enhanced Spectrum and Reduced Side Effects for Arboviral Diseases

Biocatalytic Heteroaromatic Amide Formation in Water Enabled by a Catalytic Tetrad and Two Access Tunnels

A Cold-Active Flavin-Dependent Monooxygenase from Janthinobacterium svalbardensis Unlocks Applications of Baeyer–Villiger Monooxygenases at Low Temperature

Mechanistic Insights into the Ene-Reductase-Catalyzed Promiscuous Reduction of Oximes to Amines

AI-assisted structural consensus-proteome prediction of human monkeypox viruses isolated within a year after the 2022 multi-country outbreak

Structure‐Based Demystification of Radical Catalysis by a Coenzyme B12 Dependent Enzyme—Crystallographic Study of Glutamate Mutase with Cofactor Homologues

Structure‐Based Demystification of Radical Catalysis by a Coenzyme B12 Dependent Enzyme—Crystallographic Study of Glutamate Mutase with Cofactor Homologues

Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine.

The catalytic machinery of the FAD-dependent AtBBE-like protein 15 for alcohol oxidation: Y193 and Y479 form a catalytic base, Q438 and R292 an alkoxide binding site

Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2

The sustainable synthesis of levetiracetam by an enzymatic dynamic kinetic resolution and an ex-cell anodic oxidation

Rational Engineered C-Acyltransferase Transforms Sterically Demanding Acyl Donors

A fungal ascorbate oxidase with unexpected laccase activity

Collaborators (12)

Bastian Daniel

Roland C Fischer

Daniel Kracher

Silvia Wallner

Wolfgang Kroutil

Lucija Sovic

Michael Prattes

Rolf Breinbauer

Helmut Bergler

Robert Kourist

Lena Parigger

Gustav Oberdorfer

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