Rolf Breinbauer

Professor

Graz University of Technology

Austria

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About

Rolf Breinbauer is a Professor at Technische Universität Graz in Austria. His research areas encompass organic chemistry, particularly in the fields of chemoselective catalysis, mRNA vaccine synthesis, and enzymatic glycosylation. His recent publications include work on Pd-catalyzed reactions, development of mRNA vaccine building blocks, and innovations in protein profiling techniques.

Articles (26)

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2025

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2022

Collaborators (18)

Ronald A. Glabonjat

Assistant Professor

Columbia University

UNITED STATES

Rolf Breinbauer

Research Interests

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Articles (26)

Inhibition of Adipose Tissue Lipolysis Treats Obesity-Related HFpEF

A general approach for activity-based protein profiling of oxidoreductases with redox-differentiated diarylhalonium warheads.

From Bones to Bugs

Efficient chemoselective sequential Pd-catalyzed Suzuki coupling of highly functionalized iodoaryl triflates

Integrated Chemoenzymatic Synthesis of the mRNA Vaccine Building Block N1‐Methylpseudouridine Triphosphate

Integrierte chemo‐enzymatische Synthese des mRNA‐Impfstoff‐Bausteins N1‐Methylpseudouridintriphosphat

One‐Pot Hetero‐Di‐C‐Glycosylation of the Natural Polyphenol Phloretin by a Single C‐Glycosyltransferase With Broad Sugar Substrate Specificity

Lipolysis-derived fatty acids are needed for homeostatic control of sterol element-binding protein-1c driven hepatic lipogenesis

Asymmetric Synthesis of Chiral 2-Cyclohexenones with Quaternary Stereocenters via Ene-Reductase Catalyzed Desymmetrization of 2,5-Cyclohexadienones

The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation

Discovery, characterization, and comparative analysis of new UGT72 and UGT84 family glycosyltransferases

Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms.

Loop 6 and the β‐hairpin flap are structural hotspots that determine cofactor specificity in the FMN‐dependent family of ene‐reductases

Design, synthesis and catalytic application of water-soluble 1,1′-bis(diphenylphosphino)ferrocene ligands

Constraining and Modifying Peptides Using Pd‐Mediated Cysteine Allylation

Front Cover: Constraining and Modifying Peptides Using Pd‐Mediated Cysteine Allylation (ChemBioChem 13/2023)

Reaction intensification for biocatalytic production of polyphenolic natural product di‐C‐β‐glucosides

Activity‐Based Protein Profiling of Oxidases and Reductases

Recent Advances in Pd‐Catalyzed Suzuki‐Miyaura Cross‐Coupling Reactions with Triflates or Nonaflates

Total synthesis of the isoquinolinium metabolite ETM-204 of Trabectidin

Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in mice

Design and synthesis of efficient fluororethylene-peptidomimetic inhibitors of dipeptidyl peptidase III (DPP3)

A Modular Synthesis of Teraryl‐Based α‐Helix Mimetics, Part 3: Iodophenyltriflate Core Fragments Featuring Side Chains of Proteinogenic Amino Acids

A Modular Synthesis of Teraryl‐Based α‐Helix Mimetics, Part 4: Core Fragments with Two Halide Leaving Groups Featuring Side Chains of Proteinogenic Amino Acids

A Modular Synthesis of Teraryl‐Based α‐Helix Mimetics, Part 5: A Complete Set of Pyridine Boronic Acid Pinacol Esters Featuring Side Chains of Proteinogenic Amino Acids

Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes

Collaborators (18)

Ronald A. Glabonjat

Karl Gruber

Julia Kriegesmann

Mahmoud Abdellatif

Roland C Fischer

Thomas Schlatzer

Silvia Wallner

Dennis Kurzbach

Conrad Kunick

Ruth Birner-Gruenberger

Gregor Gorkiewicz

Bernd Nidetzky

Michael Prattes

Peter Macheroux

Ellen L. Zechner

Sabine Kienesberger

Martin Pfeiffer

Thomas Züllig

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