Dustin Flanagan

Has grant

Lab head

IITB-Monash Research Academy

Australia

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About

Dustin Flanagan is a Lab Head at Monash University Monash eResearch Centre in Australia. His research areas focus on gastrointestinal oncology and the mechanisms of intestinal tumorigenesis, with recent publications exploring the roles of TGFβ signaling and Wnt receptor interactions in cancer development. His work also includes innovative models for studying gastric tissue damage and repair using organoids.

Recent Grants

Grant: Close

Targeting Wnt signalling in epithelial stem cells

Open Date: 2017-07-01

Close Date: 2018-03-01

Grant: Close

Targeting Frizzled-7 in gastric cancer

Open Date: 2017-06-01

Close Date: 2017-06-01

Grant: Close

Changing personalised cancer therapy: Establishing Australia’s cancer patient-derived organoid biobank

Open Date: 2016-09-01

Close Date: 2016-09-01

Grant: Close

Wnt/Fzd signalling in gastric cancer; molecular targets for the development of innovative anti-cancer drugs

Open Date: 2016-07-01

Close Date: 2017-06-01

Grant: Close

Targeted inhibition of Wnt cell surface receptors as a novel therapy for gastric cancer

Open Date: 2016-01-01

Close Date: 2016-12-01

Articles (10)

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2025

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2025

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2023

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2022

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2021

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2021

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2021

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2021

Year:

2021

Year:

2020

Collaborators (17)

Pauliina Kallio

University of Helsinki

FINLAND

Dustin Flanagan

Research Interests

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About

Recent Grants

Articles (10)

Breaking and Remaking: Using Organoids to Model Gastric Tissue Damage and Repair

Targeting Cancer with Paris’ Arrow: An Updated Perspective on Targeting Wnt Receptor Frizzled 7

Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features (Nature Communications, (2022), 13, 1, (7551), 10.1038/s41467-022-35134-3)

Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features.

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.

MNK inhibition sensitizes KRAS-Mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and C-MYC expression

Expression of R-Spondin 1 in Apc Mice Suppresses Growth of Intestinal Adenomas by Altering Wnt and Transforming Growth Factor Beta Signaling

Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas

Calorie Restriction Increases the Number of Competing Stem Cells and Decreases Mutation Retention in the Intestine

Collaborators (17)

Pauliina Kallio

Emma M. Kerr

Andrey Anisimov

Pirjo Nummela

Patrizia Cammareri

Philip Dunne

Saskia J E Suijkerbuijk

Johanna Englund

John Knight

Kristina Kirschner

Arafath Kaja Najumudeen

Mark Lawler

Alberto Bardelli

Owen J. Sansom

David Michael Gay

Alexander Raven

Hayley L. Belnoue-Davis

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