Laura Pasetto

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Head of Unit

Istituto di Ricerche Farmacologiche Mario Negri

Italy

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About

Laura Pasetto is the Head of Unit at the Istituto di Ricerche Farmacologiche Mario Negri in Italy. Her research primarily focuses on amyotrophic lateral sclerosis (ALS), exploring long-term survival rates in clinical trials and the biological effects of treatments. Additionally, she investigates the relationship between gut health and seizure activity in epilepsy, as well as cognitive deficits following traumatic brain injuries. Her recent studies highlight the importance of molecular pathways and patient subgroups in developing targeted therapies.

Recent Grants

Grant: Close

Towards a PERsonalized MEdicine in amyotrophic lateral sclerosis (ALS) by a patient-tailored genetic/biomarker/iPSC combined approach – PERMEALS

Open Date: 2023-05-01

Close Date: 2025-04-01

Grant: Close

A mechanism-based gene therapy approach for TDP-43 proteinopathies: a proof-of-concept study in frontotemporal dementia and traumatic brain injury.

Open Date: 2021-10-01

Close Date: 2024-09-01

Grant: Close

TDP-43 pathology and Lys-acetylation in circulating lymphomonocytes as biomarkers and therapeutic hints for amyotrophic lateral sclerosis

Open Date: 2019-01-01

Close Date: 2023-01-01

Grant: Close

Extracellular vesicles RNA: role in Amyotrophic Lateral Sclerosis pathogenesis and in patients Profiling.

Open Date: 2017-01-01

Close Date: 2020-01-01

Grant: Close

Role of Cyclophilin A in a mouse model of Amyotrophic Lateral Sclerosis

Open Date:

Close Date:

Articles (16)

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2024

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2021

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2021

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2020

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2020

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2020

Collaborators (19)

Robin Khatri

University Medical Center Hamburg-Eppendorf

GERMANY

Laura Pasetto

Research Interests

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About

Recent Grants

Articles (16)

Changes in glial cell activation and extracellular vesicles production precede the onset of disease symptoms in transgenic hSOD1<sup>G93A</sup> pigs

Early treatment with rifaximin during epileptogenesis reverses gut alterations and reduces seizure duration in a mouse model of acquired epilepsy

Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target

Colchicine treatment in amyotrophic lateral sclerosis: Safety, biological and clinical effects in a randomized clinical trial

Long-term survival of participants in a phase II randomized trial of RNS60 in amyotrophic lateral sclerosis

Sunitinib-mediated inhibition of STAT3 in skeletal muscle and spinal cord does not affect the disease in a mouse model of ALS

Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury

Efficient SARS-CoV-2 infection antagonization by rhACE2 ectodomain multimerized onto the Avidin-Nucleic-Acid-NanoASsembly

Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial

Markers of blood-brain barrier disruption increase early and persistently in COVID-19 patients with neurological manifestations

Contingent intramuscular boosting of P2XR7 axis improves motor function in transgenic ALS mice

Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia

Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis

Trabectedin and lurbinectedin extend survival of mice bearing c26 colon adenocarcinoma, without affecting tumor growth or cachexia

A Novel HGF/SF Receptor (MET) Agonist Transiently Delays the Disease Progression in an Amyotrophic Lateral Sclerosis Mouse Model by Promoting Neuronal Survival and Dampening the Immune Dysregulation

Diagnostic and prognostic values of PBMC proteins in amyotrophic lateral sclerosis

Collaborators (19)

Robin Khatri

Manuela Basso

Giulia Cagnotti

Gabriele Mora

margherita morpurgo

Alberto Doretti

Marc Sturm

Silvia Pozzi

Mariarita Galbiati

Francesco Ingravalle

Hugo de Jonge

Maria Pennuto

Silvia Faravelli

Stefano Callegaro

ANDREA MATTAREI

Sotirios Vasileiadis

Federico Forneris

Rosanna Piccirillo

Ezia Bello

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