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Laurent Decosterd

Head of the Laboratory of Clinical Pharmacology / Scientific & Administrative Head

Centre Hospitalier Universitaire Vaudois

Switzerland

Research Interests

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About

Laurent Decosterd is the Head of the Laboratory of Clinical Pharmacology and an Associated Professor at the Centre Hospitalier Universitaire Vaudois in Switzerland. His research focuses on therapeutic drug monitoring, precision dosing, and the pharmacokinetics of various medications, as evidenced by his recent publications on Janus kinase inhibitors and dosing individualization for antibiotics and antiseizure medications. He also investigates the clinical implications of drug levels in the treatment of viral infections and the efficacy of drug removal techniques.

Articles (34)

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Collaborators (29)

Sylvain Blanchon

Medecin associé, responsable d'unité

Lausanne University Hospital

SWITZERLAND

Laurent Decosterd

Research Interests

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About

Articles (34)

Therapeutic Drug Monitoring and Point-of-Care Technologies: Opportunities and Current Challenges

Population Pharmacokinetics of Levosimendan and its Metabolites OR-1855 and OR-1896 in Critically Ill Adults, Neonates and Infants on Veno-Arterial ECMO

Ruxolitinib Pharmacokinetics and Exposure–Toxicity Relationship in Hematologic Malignancies and Immune‐Mediated Diseases: A Prospective Observational Study

Therapeutic drug monitoring-guided treatment of XDR TB with an RpoB I491F mutation-a case report.

Towards model-informed precision dosing of clofazimine, moxifloxacin, and terizidone/cycloserine in the treatment of drug-resistant tuberculosis: An external model evaluation study.

Pharmacokinetics of levosimendan in critically Ill children on extracorporeal membrane oxygenation: a prospective observational study

Removal of psychotropic drugs by hemoadsorption with the HA380 cartridge

Therapeutic Drug Monitoring for Precision Dosing of Janus Kinase Inhibitors: Protocol for a Prospective Observational Study

A Liquid Chromatography-Tandem Mass Spectrometry Method for the Quantification of Cystic Fibrosis Drugs (Caftors) in Plasma and Its Application for Therapeutic Monitoring

Individualization of piperacillin dosage based on therapeutic drug monitoring with or without model-informed precision dosing: a scenario analysis

Removal of Ticagrelor by Hemoadsorption with the HA380 Cartridge

Is Nonsustained Viral Suppression With Long-Acting Cabotegravir and Rilpivirine Really Independent of Drug Levels?

Antibacterial and antifungal drug concentrations in intra-abdominal abscesses: a prospective clinical study

Is the salivary concentration of lamotrigine and levetiracetam associated with clinical outcome?

Clinical value of saliva therapeutic drug monitoring of newer antiseizure medications.

Population-Based Prevalence of Antibiotic Residuals in Low, Moderate and High Malaria Endemicity Areas in Tanzania.

Therapeutic drug monitoring of Janus kinase inhibitors for precision dosing: where do we stand ?

Sorafenib plus selective internal radiotherapy with &lt;sup&gt;90&lt;/sup&gt;Y resin microspheres for the treatment of uveal melanoma with liver metastasis: a phase I trial.

Pharmacokinetics of rifampicin and isoniazid in patients with HIV-tuberculosis coinfection receiving efavirenz-based antiretroviral treatment: an ANRS12292-RIFAVIRENZ sub-study.

Population Pharmacokinetics of Propofol in Critically Ill Patients with and Without Extracorporeal Membrane Oxygenation.

A comparison between venous blood sampling and capillary volumetric absorptive microsampling for antibiotics levels monitoring in individuals with and without periodontal disease.

Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells

Highly sensitive ultra-high-performance liquid chromatography coupled with tandem mass spectrometry method for the multiplex analysis of levosimendan and its metabolites OR-1855 and OR-1896 in human plasma

Importance of sex-dependent differences for dosing selection and optimization of chemotherapeutic drugs

Pretomanid-resistant tuberculosis.

Precision Oncology by Point-of-Care Therapeutic Drug Monitoring and Dosage Adjustment of Conventional Cytotoxic Chemotherapies: A Perspective

Population pharmacokinetic modelling to characterize the effect of chronic kidney disease on tenofovir exposure after tenofovir alafenamide administration

Simultaneous kinetics of oral vorinostat in plasma and cerebrospinal fluid in a patient with cutaneous T-cell lymphoma with CNS involvement.

Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies.

Development and validation of a liquid chromatography coupled to tandem mass spectrometry method for the monitoring of temsavir plasma concentrations in people living with HIV.

Optimized LC-MS/MS quantification of tuberculosis drug candidate macozinone (PBTZ169), its dearomatized Meisenheimer Complex and other metabolites, in human plasma and urine.

Transfer of antiretroviral drugs into breastmilk: a prospective study from the Swiss Mother and Child HIV Cohort Study

Treatment-emergent adverse events and antiseizure medication actual drug load.

Treatment-emergent adverse events and antiseizure medication actual drug load

Collaborators (29)

Sylvain Blanchon

John Prior

Jakob R Passweg

Taku Furukawa

Thierry Buclin

Nicolas Widmer

Yann Thoma

Olivier Michielin

Benoit Guery

Maria Salgado

Chin B. Eap

Katharina Kusejko

Asier Sáez-Cirión

Matthias Merker

Maxime HENTZIEN

Michel Cuendet

Angela Koutsokera

Aimable Nahimana

Rinaldo Bellomo

Yugeesh R. Lankadeva

Francoise Livio

Matthias Cavassini

Monia Guidi

Catia Marzolini

Maria-Helena Perez

FX Blanc

Andrea O. Rossetti

François R Girardin

Stefan Niemann

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Sorafenib plus selective internal radiotherapy with <sup>90</sup>Y resin microspheres for the treatment of uveal melanoma with liver metastasis: a phase I trial.