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Matthias Merker

Assistant Professor

Research Center Borstel - Leibniz Lung Center

Germany

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Research Interests

Microbiology

80%

Epidemiology

40%

Antibiotic Resistance

80%

Tuberculosis Research

60%

Tuberculosi

40%

Antimicrobial Research

30%

Molecular Epidemiology

30%

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Articles20

Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen Haemophilus influenzae

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Year:

2025

Serratia sp. traits distinguish the lung microbiome of patients with tuberculosis and non-tuberculous mycobacterial lung diseases

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Year:

2025

GlnA3 Mt is able to glutamylate spermine but it is not essential for the detoxification of spermine in Mycobacterium tuberculosis

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Year:

2025

Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach

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Year:

2024

Refined understanding of the impact of the <i>Mycobacterium tuberculosis</i> complex diversity on the intrinsic susceptibility to pretomanid.

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Year:

2024

Revisiting mutational resistance to ampicillin and cefotaxime in Haemophilus influenzae.

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Year:

2024

A composite reference standard is needed for bedaquiline antimicrobial susceptibility testing forMycobacterium tuberculosiscomplex

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Year:

2024

Use of Whole Genome Sequencing for Mycobacterium tuberculosis Complex Antimicrobial Susceptibility Testing.

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Year:

2024

Use of Whole Genome Sequencing for Mycobacterium tuberculosis Complex Antimicrobial Susceptibility Testing: From Sequence Data to Resistance Profiles.

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Year:

2024

Limited Nosocomial Transmission of Drug-Resistant Tuberculosis, Moldova.

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Year:

2023

Transmission Dynamics of a Mycobacterium tuberculosis Complex Outbreak in an Indigenous Population in the Colombian Amazon Region.

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Year:

2023

Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysis.

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Year:

2023

Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a 2023 TBnet/RESIST-TB consensus statement.

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Year:

2023

Pretomanid-resistant tuberculosis.

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Year:

2023

Two-stage tuberculosis diagnostics: combining centrifugal microfluidics to detect TB infection and Inh and Rif resistance at the point of care with subsequent antibiotic resistance profiling by targeted NGS.

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Year:

2023

A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.

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Year:

2022

Delineating Mycobacterium abscessus population structure and transmission employing high-resolution core genome multilocus sequence typing.

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Year:

2022

Diagnostic performance of the AID line probe assay in the detection of Mycobacterium tuberculosis and drug resistance in Romanian patients with presumed TB.

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Year:

2022

Genome-wide association studies of global Mycobacterium tuberculosis resistance to 13 antimicrobials in 10,228 genomes identify new resistance mechanisms.

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Year:

2022

High fluoroquinolone resistance proportions among multidrug-resistant tuberculosis driven by dominant L2 Mycobacterium tuberculosis clones in the Mumbai Metropolitan Region.

Article Link

Year:

2022

Collaborators9

Wim Mulders

Institute of Tropical Medicine Antwerp

BELGIUM

Ted Cohen

Professor

Yale School of Public Health

UNITED STATES

Sarah Earle

University of Oxford

UNITED KINGDOM

Philip Fowler

University of Oxford

UNITED KINGDOM

Bouke de Jong

Head, Mycobacteriology Unit

Instituut voor Tropische Geneeskunde

BELGIUM

Sebastien Gagneux

Professor & Head of Department

Swiss Tropical and Public Health Institute

SWITZERLAND

Claudio Köser

University of Cambridge

UNITED KINGDOM

Gillian Rodger

University of Oxford

UNITED KINGDOM

Laurent Decosterd

Head of the Laboratory of Clinical Pharmacology / Associated Professor

Centre Hospitalier Universitaire Vaudois

SWITZERLAND

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