Matthias Merker

Assistant Professor

Research Center Borstel - Leibniz Lung Center

Germany

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Matthias Merker is an Assistant Professor at the Research Center Borstel - Leibniz Lung Center in Germany. His research focuses on antibiotic resistance, particularly in Mycobacterium tuberculosis and Haemophilus influenzae, exploring topics such as genetic determinants of resistance and the application of Whole Genome Sequencing for antimicrobial susceptibility testing. Recent publications highlight the complexity of lung microbiomes in tuberculosis and non-tuberculous mycobacterial diseases and the implications of beta-lactam resistance in human pathogens.

Articles (20)

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2025

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2022

Collaborators (9)

Wim Mulders

Institute of Tropical Medicine Antwerp

BELGIUM

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Ted Cohen

Professor

Yale School of Public Health

UNITED STATES

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Sarah Earle

University of Oxford

UNITED KINGDOM

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Philip Fowler

Associate Professor

University of Oxford

UNITED KINGDOM

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Bouke de Jong

Head, Mycobacteriology Unit

Instituut voor Tropische Geneeskunde

BELGIUM

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Sebastien Gagneux

Professor & Head of Department

Swiss Tropical and Public Health Institute

SWITZERLAND

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Claudio Köser

University of Cambridge

UNITED KINGDOM

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Gillian Rodger

University of Oxford

UNITED KINGDOM

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Laurent Decosterd

Head of the Laboratory of Clinical Pharmacology / Associated Professor

Centre Hospitalier Universitaire Vaudois

SWITZERLAND

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Matthias Merker

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Articles (20)

Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen Haemophilus influenzae

Serratia sp. traits distinguish the lung microbiome of patients with tuberculosis and non-tuberculous mycobacterial lung diseases

GlnA3 Mt is able to glutamylate spermine but it is not essential for the detoxification of spermine in Mycobacterium tuberculosis

Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach

Refined understanding of the impact of the <i>Mycobacterium tuberculosis</i> complex diversity on the intrinsic susceptibility to pretomanid.

Revisiting mutational resistance to ampicillin and cefotaxime in Haemophilus influenzae.

A composite reference standard is needed for bedaquiline antimicrobial susceptibility testing forMycobacterium tuberculosiscomplex

Use of Whole Genome Sequencing for Mycobacterium tuberculosis Complex Antimicrobial Susceptibility Testing.

Use of Whole Genome Sequencing for Mycobacterium tuberculosis Complex Antimicrobial Susceptibility Testing: From Sequence Data to Resistance Profiles.

Limited Nosocomial Transmission of Drug-Resistant Tuberculosis, Moldova.

Transmission Dynamics of a Mycobacterium tuberculosis Complex Outbreak in an Indigenous Population in the Colombian Amazon Region.

Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysis.

Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a 2023 TBnet/RESIST-TB consensus statement.

Pretomanid-resistant tuberculosis.

Two-stage tuberculosis diagnostics: combining centrifugal microfluidics to detect TB infection and Inh and Rif resistance at the point of care with subsequent antibiotic resistance profiling by targeted NGS.

A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.

Delineating Mycobacterium abscessus population structure and transmission employing high-resolution core genome multilocus sequence typing.

Diagnostic performance of the AID line probe assay in the detection of Mycobacterium tuberculosis and drug resistance in Romanian patients with presumed TB.

Genome-wide association studies of global Mycobacterium tuberculosis resistance to 13 antimicrobials in 10,228 genomes identify new resistance mechanisms.

High fluoroquinolone resistance proportions among multidrug-resistant tuberculosis driven by dominant L2 Mycobacterium tuberculosis clones in the Mumbai Metropolitan Region.

Collaborators (9)

Wim Mulders

Ted Cohen

Sarah Earle

Philip Fowler

Bouke de Jong

Sebastien Gagneux

Claudio Köser

Gillian Rodger

Laurent Decosterd

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