Lei Liu

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Assistant Professor of Neurology

Harvard Medical School

United States

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Dr. Lei Liu is an Assistant Professor of Neurology at Harvard Medical School, USA. His research primarily focuses on Alzheimer's disease and neurodegenerative disorders, exploring topics such as the pathogenicity of PSEN variants, tau phosphorylation in Alzheimer's patients, and the dynamics of α-synuclein phosphorylation. His recent publications contribute to a deeper understanding of disease mechanisms and potential therapeutic strategies in neurology.

Recent Grants

Grant: Close

A previously unrecognized β/γ-secretases complex as a therapeutic target for AD

Open Date: 2019-04-01

Close Date: 2021-03-01

Grant: Close

Diagnostic treatment of Alzheimer's disease based on a novel molecule ILEI to control the brain Aβ production

Open Date: 2015-04-01

Close Date: 2018-03-31

Articles (12)

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2024

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2024

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2022

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2022

Collaborators (7)

Ulf Dettmer

Assistant Professor of Neurology

Brigham and Women's Hospital

UNITED STATES

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Gary Ho

Assistant Professor

Harvard Medical School

UNITED STATES

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Jonathan Vogelgsang

Harvard University

UNITED STATES

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Nick Fox

Professor and Head of Department

UCL Institute of Neurology, University College London

UNITED KINGDOM

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Yang Yang

Van Andel Institute

UNITED STATES

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Dennis J. Selkoe

Vincent and Stella Coates Professor of Neurologic Diseases

Harvard Medical School

UNITED STATES

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Guy Caldwell

University Distinguished Research Professor

The University of Alabama

UNITED STATES

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Lei Liu

Research Interests

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Recent Grants

Articles (12)

Uncovering elevated tau TPP motif phosphorylation in the brain of Alzheimer's disease patients

The pathogenicity of PSEN2 variants is tied to Aβ production and homology to PSEN1

Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal‐dominant Alzheimer's disease

Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains.

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity.

Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy

Generation and application of semi-synthetic p-Tau181 calibrator for immunoassay calibration

Aβ oligomers from human brain impair mossy fiber LTP in CA3 of hippocampus, but activating cAMP-PKA and cGMP-PKG prevents this

Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer's disease.

Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations

Variant-dependent heterogeneity in amyloid β burden in autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analyses of an observational study.

A calcium-sensitive antibody isolates soluble amyloid-β aggregates and fibrils from Alzheimer's disease brain.

Collaborators (7)

Ulf Dettmer

Gary Ho

Jonathan Vogelgsang

Nick Fox

Yang Yang

Dennis J. Selkoe

Guy Caldwell

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