Guy Caldwell

University Distinguished Research Professor

The University of Alabama

United States

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Guy Caldwell is a University Distinguished Research Professor at the University of Alabama, USA. His research primarily focuses on the mechanisms underlying dopaminergic neurodegeneration and neuroprotection, particularly in the context of Parkinson's and Alzheimer's diseases. Recent studies include investigations into xanthine dehydrogenase modulation and the effects of bacterial metabolites on neurodegeneration, utilizing C. elegans as a model organism.

Articles (10)

Year:

2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2021

Year:

2021

Collaborators (7)

Han-A Park

Assistant Professor

The University of Alabama

UNITED STATES

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Lei Liu

Assistant Professor of Neurology

Harvard Medical School

UNITED STATES

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Ulf Dettmer

Assistant Professor of Neurology

Brigham and Women's Hospital

UNITED STATES

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Kim Caldwell

Professor

The University of Alabama

UNITED STATES

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Gary Ho

Assistant Professor

Harvard Medical School

UNITED STATES

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Mikko Taipale

Associate Professor

University of Toronto

CANADA

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Dirk Fasshauer

Associate Professor

University of Lausanne

SWITZERLAND

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Guy Caldwell

Research Interests

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Articles (10)

Attenuation of Dopaminergic Neurodegeneration in a <i>C. elegans</i> Parkinson’s Model through Regulation of Xanthine Dehydrogenase (XDH-1) Expression by the RNA Editase, ADR-2

Xanthine Dehydrogenase Is a Modulator of Dopaminergic Neurodegeneration in Response to Bacterial Metabolite Exposure in <i>C. elegans</i>

Integrated regulation of dopaminergic and epigenetic effectors of neuroprotection in Parkinson’s disease models

Mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a Caenorhabditis elegans α-synuclein model of Parkinson's disease

Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow

From bugs to bedside: functional annotation of human genetic variation for neurological disorders using invertebrate models

Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy

Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans

A conformational switch driven by phosphorylation regulates the activity of the evolutionarily conserved SNARE Ykt6

Conserved nicotine-activated neuroprotective pathways involve mitochondrial stress

Collaborators (7)

Han-A Park

Lei Liu

Ulf Dettmer

Kim Caldwell

Gary Ho

Mikko Taipale

Dirk Fasshauer

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