Leonard Nelson

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Professor of Human Liver Biological Engineering

Edinburgh Napier University

United Kingdom

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About

Professor Leonard Nelson is a faculty member at Edinburgh Napier University in the United Kingdom, where he specializes in Human Liver Biological Engineering. His recent research includes studies on drug-induced liver injury, non-invasive toxicity monitoring, and molecular mechanisms in cholangiocarcinoma. With a focus on advancing preclinical models and therapeutic strategies, he contributes significantly to the understanding of liver diseases and their treatments.

Recent Grants

Grant: Open

halt-RONIN: Discovering chronic inflammation biomarkers that define key stages in the Healthy-to-NASH (non-alcoholic steatohepatitis) transition to inform early prevention and treatment strategies

Open Date: 2022-12-01

Close Date: 2026-11-30

Grant: Close

Nanopatterned Human Liver BioChips for Drug Hepatotoxicity Screening

Open Date: 2014-07-31

Close Date: 2016-07-30

Grant: Close

Development of a bioartificial liver therapy in acute liver failure

Open Date: 2012-06-01

Close Date: 2015-05-01

Grant: Close

Tissue Engineering of 3D Human Hepatic Organotypic Model Using Novel Cell, Biomatrix and Bioreactor Enabling Technologies for Pharmaceutical Applications

Open Date: 2011-12-01

Close Date: 2013-02-01

Articles (10)

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2024

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2024

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2024

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2023

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2022

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2022

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2021

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2021

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2021

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2020

Collaborators (16)

María J Iraburu

Professor

Universidad de Navarra

SPAIN

Leonard Nelson

Research Interests

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About

Recent Grants

Articles (10)

Roadmap to DILI research in Europe. A proposal from COST action ProEuroDILINet

Non-invasive methods of monitoring Fe3O4 magnetic nanoparticle toxicity in human liver HepaRG cells using impedance biosensing and Coherent anti-Stokes Raman spectroscopic (CARS) microscopy

Control compounds for preclinical drug-induced liver injury assessment: Consensus-driven systematic review by the ProEuroDILI network

Lack of Cyclin E1 in hepatocytes aggravates ethanol-induced liver injury and hepatic steatosis in experimental murine model of acute and chronic alcohol-associated liver disease.

New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming

Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy.

Activation of the Unfolded Protein Response (UPR) Is Associated with Cholangiocellular Injury, Fibrosis and Carcinogenesis in an Experimental Model of Fibropolycystic Liver Disease

Next-generation sequencing of bile cell-free DNA for the early detection of patients with malignant biliary strictures

Advanced preclinical models for evaluation of drug-induced liver injury – consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]

Dual targeting of G9a and DNMT1 for the treatment of experimental cholangiocarcinoma

Collaborators (16)

María J Iraburu

Maria Elizalde

pierre bagnaninchi

Roger Davis

Ángeles López-Gonzálvez

Maite G. Fernández-Barrena

EDUARDO MARTINEZ-NAVES

Rafael Bañares

Michel Kranendonk

Francisco Javier Cubero

Juan J Vila

Angeles López-López

Humphrey Yiu

Chiara Braconi

Sergio Morini

August Vidal

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