Lesley Hoyles

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Professor

University of Nottingham

United Kingdom

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About

Professor Lesley Hoyles is a faculty member at Nottingham Trent University in the United Kingdom. Her research primarily focuses on the roles of microbiota in health and disease, particularly in the context of gastrointestinal microbiology and its implications for conditions such as non-alcoholic fatty liver disease and colorectal cancer. Recent publications highlight her work on diverse topics including pathogen interactions, microbial genomics, and the systemic effects of microbial metabolites.

Recent Grants

Grant: Close

Hamied Foundation UK-India AMR Visiting Professorship

Open Date: 2019-12-01

Close Date: 2020-11-01

Grant: Close

International Exchange

Open Date: 2019-09-01

Close Date: 2021-08-01

Grant: Close

Precision medicine through integrative metagenomics and phenomics in a human NAFLD cohort

Open Date: 2019-01-01

Close Date: 2021-01-01

Grant: Close

Metagenomics: Assessment of Routine Methods And Later Analysis (MARMALAde).

Open Date: 2017-10-01

Close Date: 2019-03-01

Grant: Close

Antimicrobial resistance in gut communities

Open Date: 2016-10-01

Close Date: 2017-07-01

Articles (18)

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2025

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2023

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2023

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2022

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2022

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2022

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2022

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2022

Collaborators (23)

Gareth McVicker

Lecturer in microbiology

Nottingham Trent University - Clifton Campus

UNITED KINGDOM

Lesley Hoyles

Research Interests

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About

Recent Grants

Articles (18)

Menadione reduces the expression of virulence- and colonization-associated genes in Helicobacter pylori

The plasmid-borne hipBA operon of Klebsiella michiganensis encodes a potent plasmid stabilization system

Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality

Human microbiome myths and misconceptions

Lytic bacteriophage vB_KmiS-Kmi2C disrupts biofilms formed by members of the <i>Klebsiella oxytoca</i> complex, and represents a novel virus family and genus

Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide

A host–gut microbial amino acid co-metabolite, p-cresol glucuronide, promotes blood–brain barrier integrity in vivo

Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer

The role of Klebsiella populations in preterm infants

Genomic analyses of Bacteroides fragilis: subdivisions I and II represent distinct species

Phenotypic and genomic characterization of Pseudomonas aeruginosa isolates recovered from catheter-associated urinary tract infections in an Egyptian hospital

Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity.

Lelliottia amnigena recovered from the lung of a harbour porpoise, and comparative analyses with Lelliottia spp.

Microbiome and metabolome features of the cardiometabolic disease spectrum.

Multi-omic phenotyping reveals host-microbe responses to bariatric surgery, glycaemic control and obesity

Extended genomic analyses of the broad-host-range phages vB_KmiM-2Di and vB_KmiM-4Dii reveal slopekviruses have highly conserved genomes

Altered immunity to microbiota, B cell activation and depleted γδ/resident memory T cells in colorectal cancer.

Altered Mucosal Immune-Microbiota Interactions in Familial Adenomatous Polyposis.

Collaborators (23)

Gareth McVicker

Sofia K. Forslund

Dominique Gauguier

Jean-Sébastien Hulot

Linda Stewart

Simon McArthur

Petros Andrikopoulos

Oluf Pedersen

Sara Vieira-Silva

Anna Castells-Nobau

Jonathan Thomas

Nicholas Penney

Gary Frost

Julien Chilloux

Václav Liška

Henrik Vestergaard

Yong Fan

David Negus

Alan Walker

Trine Nielsen

Peishun Li

Antonis Myridakis

Simon Cameron

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