Lisa Sharkey

University of Michigan

United States

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Articles (15)

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2025

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2025

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2020

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2020

Collaborators (10)

Shannon Moore

University of Michigan

UNITED STATES

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Nicholas Kanaan

Associate Professor

Michigan State University College of Human Medicine

UNITED STATES

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Sami Barmada

University of Michigan

UNITED STATES

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Eeva-Liisa Eskelinen

University of Helsinki

FINLAND

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Jacqueline Welday

National Institutes of Health

UNITED STATES

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Erpan Ahat

University of Michigan

UNITED STATES

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Phyllis Hanson

University of Michigan

UNITED STATES

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Takahiro Seki

Visiting Professor

Kumamoto University

JAPAN

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Shyamal Mosalaganti

Assistant Professor

University of Michigan

UNITED STATES

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Henry Paulson

University of Michigan

UNITED STATES

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Lisa Sharkey

Research Interests

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Articles (15)

Facile generation of drug-like conformational antibodies specific for amyloid fibrils.

Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology

Pathogenic mutations in UBQLN2 exhibit diverse aggregation propensity and neurotoxicity

Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and alter their functional properties.

The gag-like gene RTL8 antagonizes PEG10-mediated virus like particles

Ubiquilin-2 regulates pathological alpha-synuclein

Flow cytometric isolation of drug-like conformational antibodies specific for amyloid fibrils.

Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components of the autophagy-lysosome pathways

Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration.

GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin

RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control.

Disrupting the Balance of Protein Quality Control Protein UBQLN2 Accelerates Tau Proteinopathy.

Shared and divergent phase separation and aggregation properties of brain-expressed ubiquilins.

Modeling UBQLN2-mediated neurodegenerative disease in mice: Shared and divergent properties of wild type and mutant UBQLN2 in phase separation, subcellular localization, altered proteostasis pathways, and selective cytotoxicity

Ubiquilin-2 differentially regulates polyglutamine disease proteins

Collaborators (10)

Shannon Moore

Nicholas Kanaan

Sami Barmada

Eeva-Liisa Eskelinen

Jacqueline Welday

Erpan Ahat

Phyllis Hanson

Takahiro Seki

Shyamal Mosalaganti

Henry Paulson

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