Nicholas Kanaan

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Associate Professor

Michigan State University College of Human Medicine

United States

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About

Nicholas Kanaan is an Associate Professor at Michigan State University, College of Human Medicine in the United States. His research focuses on tau protein interactions and modifications, with recent articles discussing the tau interactome, the effects of polyamination on tau conformations, and potential therapeutic targets for frontotemporal dementia. He is also involved in studies aimed at improving memory techniques for older adults and analyzing the impact of post-translational modifications on tau pathology.

Recent Grants

Grant: Close

Tau-induced axonal degeneration in Alzheimer's disease and tauopathies

Open Date: 2014-09-30

Close Date: 2019-04-30

Grant: Close

Tau Conformation in Tauopathies and Neuronal Function

Open Date: 2014-04-15

Close Date: 2019-03-31

Grant: Close

Tau Conformation in Tauopathies and Neuronal Function

Open Date: 2014-04-15

Close Date: 2019-03-31

Articles (19)

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2020

Collaborators (6)

Masamichi Ikawa

Professor

University of Fukui

JAPAN

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Benjamin Combs

Assistant Professor

Michigan State University

UNITED STATES

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Lulu Jiang

Assistant Professor

University of Virginia

UNITED STATES

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Abhijit Chaudhari

Assistant Professor

University of California, Davis

UNITED STATES

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Kohji Mori

Associate Professor

Osaka University

JAPAN

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Lisa Sharkey

University of Michigan

UNITED STATES

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Nicholas Kanaan

Research Interests

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About

Recent Grants

Articles (19)

BioID2-Based Tau Interactome Reveals Novel and Known Protein Interactions Associated with Multiple Cellular Pathways

Polyamination with spermidine enhances pathogenic tau conformations while reducing filamentous aggregate formation in vitro

iPSC screening identifies CACNA2D2 as a potential therapeutic target for FTLD-Tau

Facile generation of drug-like conformational antibodies specific for amyloid fibrils.

O-GlcNAc modification differentially regulates microtubule binding and pathological conformations of tau isoforms in vitro

Strengthening older adults remembering (SOARing): Research protocol for a multi-site randomized clinical trial examining the efficacy of the Kessler Foundation modified story memory technique (KF-mSMT®) in mild cognitive impairment (MCI)

Biochemical approaches to assess the impact of post-translational modifications on pathogenic tau conformations using recombinant protein

Tau here, tau there, tau almost everywhere: Clarifying the distribution of tau in the adult CNS

Temporal progression of tau pathology and neuroinflammation in a rhesus monkey model of Alzheimer's disease

Syk inhibitors reduce tau protein phosphorylation and oligomerization

Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons

EFhd2 brain interactome reveals its association with different cellular and molecular processes

Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein

Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey.

Tau: A Signaling Hub Protein.

TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau.

Tau is not necessary for amyloid-β-induced synaptic and memory impairments.

Liquid-liquid phase separation induces pathogenic tau conformations in vitro.

A human induced pluripotent stem cell-derived cortical neuron human-on-a chip system to study Aβ42 and tau-induced pathophysiological effects on long-term potentiation.

Collaborators (6)

Masamichi Ikawa

Benjamin Combs

Lulu Jiang

Abhijit Chaudhari

Kohji Mori

Lisa Sharkey

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