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Lyn-Marie Birkholtz

Professor and Research Chair

Stellenbosch University

South Africa

Research Interests

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Professors in Pharmaceutical Chemistry

Articles (20)

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2026

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2024

Collaborators (7)

Andries Engelbrecht

Stellenbosch University

SOUTH AFRICA

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Colin Sutherland

Professor of Parasitology

London School of Hygiene and Tropical Medicine Faculty of Infectious and Tropical Diseases

UNITED KINGDOM

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Marcus Lee

Professor

University of Dundee

UNITED KINGDOM

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Chiara Borsari

Tenure-Track Assistant Professor (RTDB)

University of Milan

ITALY

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Kathryn J Wicht

Lecturer and Research Group Leader

University of Cape Town

SOUTH AFRICA

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Beatriz Baragaña

Academic, Principal Investigator/Senior Lecturer (Teaching and Research)

University of Dundee

UNITED KINGDOM

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Elizabeth Winzeler

Professor

University of California, San Diego

UNITED STATES

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Lyn-Marie Birkholtz

Research Interests

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Articles (20)

A Novel Class of Orally Bioavailable Phenylglycine–Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action

Self-organizing Maps for Missing Value Imputation in Transcriptomic Datasets

From pan-active to parasite-selective antiparasitic agents: A scaffold hopping approach

Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining

Characterizing the quick-killing mechanism of action of azithromycin analogs against malaria parasites

Ferrocenyl Quinoline-Benzimidazole Hybrids: A Multistage Strategy to Combat Drug-Resistant Malaria

Medicinal Chemistry Progression of Sapanisertib, the Anticancer and Dual Plasmodium Phosphatidylinositol 4-Kinase Beta and cGMP-Dependent Protein Kinase Inhibitor, for Malaria

Novel Inhibitors of Plasmodium Phosphatidylinositol 4-kinase IIIβ with Low Propensity for Resistance: Life Cycle Stage Activity and In Vivo Efficacy in a Humanized Mouse Malaria Infection Model

Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1

Synthesis and SAR Studies of Acyl-Thiourea Platinum(II) Complexes Yield Analogs with Dual-Stage Antiplasmodium Activity

Targeting Aurora Kinases as Essential Cell-Cycle Regulators to Deliver Multi-Stage Antimalarials Against Plasmodium Falciparum

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of <i>Plasmodium falciparum</i> Phosphatidylinositol-4-kinase and Hemozoin Formation with <i>In Vivo</i> Efficacy.

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo

Eliminating malaria transmission requires targeting immature and mature gametocytes through lipoidal uptake of antimalarials

Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration

Genetic complexity alters drug susceptibility of asexual and gametocyte stages of Plasmodium falciparum to antimalarial candidates

Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission

Phytoconstituents from Turraea obtusifolia and their antiplasmodial activity

The Tuberculosis Drug Candidate SQ109 and Its Analogs Have Multistage Activity against Plasmodium falciparum

Collaborators (7)

Andries Engelbrecht

Colin Sutherland

Marcus Lee

Chiara Borsari

Kathryn J Wicht

Beatriz Baragaña

Elizabeth Winzeler

Make your next move.

Lyn-Marie Birkholtz

Research Interests

Make your next move.

Explore related searches

Articles (20)

A Novel Class of Orally Bioavailable Phenylglycine–Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action

Self-organizing Maps for Missing Value Imputation in Transcriptomic Datasets

From pan-active to parasite-selective antiparasitic agents: A scaffold hopping approach

Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining

Characterizing the quick-killing mechanism of action of azithromycin analogs against malaria parasites

Ferrocenyl Quinoline-Benzimidazole Hybrids: A Multistage Strategy to Combat Drug-Resistant Malaria

Medicinal Chemistry Progression of Sapanisertib, the Anticancer and Dual Plasmodium Phosphatidylinositol 4-Kinase Beta and cGMP-Dependent Protein Kinase Inhibitor, for Malaria

Novel Inhibitors of Plasmodium Phosphatidylinositol 4-kinase IIIβ with Low Propensity for Resistance: Life Cycle Stage Activity and In Vivo Efficacy in a Humanized Mouse Malaria Infection Model

Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1

Synthesis and SAR Studies of Acyl-Thiourea Platinum(II) Complexes Yield Analogs with Dual-Stage Antiplasmodium Activity

Targeting Aurora Kinases as Essential Cell-Cycle Regulators to Deliver Multi-Stage Antimalarials Against Plasmodium Falciparum

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of &lt;i&gt;Plasmodium falciparum&lt;/i&gt; Phosphatidylinositol-4-kinase and Hemozoin Formation with &lt;i&gt;In Vivo&lt;/i&gt; Efficacy.

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo

Eliminating malaria transmission requires targeting immature and mature gametocytes through lipoidal uptake of antimalarials

Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration

Genetic complexity alters drug susceptibility of asexual and gametocyte stages of Plasmodium falciparum to antimalarial candidates

Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission

Phytoconstituents from Turraea obtusifolia and their antiplasmodial activity

The Tuberculosis Drug Candidate SQ109 and Its Analogs Have Multistage Activity against Plasmodium falciparum

Collaborators (7)

Andries Engelbrecht

Colin Sutherland

Marcus Lee

Chiara Borsari

Kathryn J Wicht

Beatriz Baragaña

Elizabeth Winzeler

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2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of <i>Plasmodium falciparum</i> Phosphatidylinositol-4-kinase and Hemozoin Formation with <i>In Vivo</i> Efficacy.